Legal Gefitinib Iressa CAS 184475-35-2 Pharmaceutical Cancer Treating Raw Material

 

Quick detail

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Name:	Gefitinib
CAS No.:	184475-35-2
Formula:	C22H24ClFN4O3
Molecular Weight:	446.90 .
Synonyms:	N-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine;ZD1839;4-(3-Chloro-4-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline; Irressat;Gefitinib (JAN/USAN);4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-;ZD 1839;4-Quinazolinamine,
Density:	1.322 g/cm3
Melting Point:	119-120 °C
Boiling Point:	586.8 °C at 760 mmHg
Flash Point:	308.7 °C
Appearance:	light-yellow crystalline powder

 

Recommended Antineoplastic products

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Lapatinib	CAS : 231277-92-2	Cisplatin	15663-27-1
Dasatinib	302962-49-8	Vincristine sulfate	2068-78-2
Axitinib	319460-85-0	Melphalan	148-82-3
Gefitinib	184475-35-2	Nimustine hydrochloride	55661-38-6
Sunitinib Malate	341031-54-7	Gemcitabine	95058-81-4
Erlotinib hydrochloride	183319-69-9 107868-30-4	Paclitaxel	33069-62-4
Doxorubicin hydrochloride	25316-40-9	Docetaxel	114977-28-5
Mitomycin C	50-07-7	(Podophyllotoxin)nsc24818	518-28-5 Recommended Antineoplastic products:
Tegafur	17902-23-7

 

Gefitinib Description :

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Gefitinib is a type of drug called a tyrosine kinase inhibitor (TKI), also known as a cancer growth inhibitor. Kinases are proteins in the body that regulate how the cells grow and divide. Gefitinib blocks (inhibits) the protein from sending signals to the cancer cells that make them grow and divide.

 

For the treatment of locally advanced or metastatic non-small cell lung cancer, after failure of both platinum-based and taxane-based chemotherapies.

Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.

 

 

Taking gefitinib

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Gefitinib is taken as a tablet once a day, about the same time each day. Take the tablet with a glass of water, with or without food.

If you have trouble swallowing tablets put the tablet in a glass of water and leave it to dissolve. It may take 20 minutes to completely dissolve. Once it’s dissolved, drink it straight away then refill the glass with water and drink it to make sure you’ve taken all of the gefitinib.

Always take your tablets exactly as your nurse or pharmacist explained. This is important to make sure they work as well as possible for you.

 

There are some important things to remember when taking your tablets:

1. If you are sick just after taking the tablets, tell your doctor as you may need to take another dose. Don't take another dose without telling your doctor first.
2. If you forget to take a tablet, take it as soon as you realise. But if there’s less than 12 hours until your next dose, don’t take it, just take your next dose at the usual time. Never take a double dose.
3. Don’t take antacids two hours before or one hour after taking gefitinib. They can affect how it works.
4. Keep tablets in the original package and at room temperature, away from heat and direct sunlight.
5. Keep them safe and out of the reach of children.
6. Get a new prescription before you run out of tablets and make sure you have plenty for holidays.
7. Return any unused tablets to the pharmacist if your treatment is stopped.

 

Possible side effects of gefitinib

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• Skin changes
• Hair and nail changes
• Eye problems
• Bladder irritation
• Liver changes

 

Gefitinib COA

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Tests	Specification	Results
Appearance	Slight white to white crystalline powder	White crystalline powder
Identification IR(1)	Conforms to the refence	Conforms to the refence
Melting Point	194.0~198.0°C	196.0~197.0°C
Water(KF)	≤0.30%	0.05%
Assay (HPLC)	≥99.0%	99.9%
Individual Purity (HPLC )	≤0.20%	0.09%
Conclusion	Conform with company standard