10 Gram	Negotiable

Min.Order :10 Gram
Purity: 99%
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162808-62-0 Caspofungin Caspofungine

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Appearance:White crystalline powder
Application:Pharmaceutical Raw Materials; Pharmaceutical Intermediate, etc
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ProductionCapacity:10|Metric Ton|Month
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Pharmaceutical Caspofungin For Treating certain fungal infections 162808-62-0

Quick detail

Product Name:	Caspofungin
Synonyms:	Caspofungine;CASPOFUNGIN;CASPORFUNGIN;Aids058650;Aids-058650;Cancidas (tm);m991;Caspofungin .CH3COOH
CAS:	162808-62-0
MF:	C53H89N9O15
MW:	1092.33
EINECS:
Product Categories:	Antifungals

Caspofungin Introduction

Caspofungin is used for:

Treating certain fungal infections.

Caspofungin is an antifungal agent. It works by weakening fungal cell walls, which allows the cell contents to leak out, resulting in the death of the fungus.

Caspofungin is used to treat a variety of serious fungal infections. It is often used in patients who cannot use or do not respond to other antifungal medications (such asamphotericin B,itraconazole). Caspofungin belongs to a class of drugs known as echinocandins. It works by stopping the growth of fungus.

Caspofungin Dosing & Uses

1. Candida Infections

Includes candidemia and other Candida infections including intra-abdominal abscesses, peritonitis, and pleural space infections
Day 1 loading dose: 70 mg IV infused over 1 hr (as a single dose)
Maintenance: 50 mg IV qDay infused over 1 hr
Continue antifungal therapy for at least 14 days after last positive culture; patients who remain persistently neutropenic may warrant longer course of therapy pending resolution of neutropenia

2. Esophageal Candidiasis

Indicated for treatment of esophageal candidiasis
50 mg IV qDay infused over 1 hr, continue for 7-14 days after symptom resolution
Loading dose not necessary, has not been studied with this indication
May consider suppressive oral therapy in patients with HIV infection because of the risk of oropharyngeal candidiasis relapse

3. Invasive Aspergillosis

Indicated for invasive aspergillosis in patients refractory to or intolerant of other therapies (eg, amphotericin B, itraconazole)
Day 1 loading dose: 70 mg IV infused over 1 hr (as a single dose)
Maintenance: 50 mg IV qDay infused over 1 hr
Duration of treatment should be based upon the severity of the underlying disease, recovery from immunosuppression, and clinical response.

4. Febrile Neutropenia

Empirical therapy for presumed fungal infections in febrile, neutropenic patients
Day 1 loading dose: 70 mg IV infused over 1 hr
Maintenance: 50 mg IV qDay infused over 1 hour; if well tolerated but not achieving adequate response, may increase to 70 mg IV qDay
Duration of treatment should be based on clinical response; continue empirical therapy until resolution of neutropenia
If fungal infection is confirmed, continue therapy for a minimum of 14 days; treatment should continue for at least 7 days after both neutropenia and clinical symptoms are resolved

5. Dosage Modifications

Coadministration with strong CYP inducers (rifampin): 70 mg IV qDay
Coadministration with other drug clearance inducers: Consider increasing to 70 mg IV qDay

6. Hepatic Impairment

Mild Child-Pugh 5-6: No dosage adjustment necessary
Moderate Child-Pugh 7-9: Load 70 mg IV, then 35 mg IV qDay
Severe Child-Pugh >9: Safety and efficacy not established

Before using caspofungin:

Some medical conditions may interact with caspofungin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have liver problems or are using cyclosporine

Some MEDICINES MAY INTERACT with caspofungin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Cyclosporine because the risk of liver problems may be increased
Carbamazepine, dexamethasone, efavirenz, nevirapine, phenytoin, or rifampin because they may decrease caspofungin's effectiveness
Tacrolimus because its effectiveness may be decreased by caspofungin

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Pharmaceutical Caspofungin For Treating certain fungal infections 162808-62-0