Raw Oral Anti Inflammatory Medicine Budesonide Powder CAS 51372-29-3

 

Quick detail

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Name:	Pregna-1,4-diene-3,20-dione,16,17-[(1R)-butylidenebis(oxy)]-11,21-dihydroxy-, (11b,16a)-
CAS No.:	51372-29-3
Formula:	C25H34O6
Molecular Weight:	430.53
Synonyms:	Pregna-1,4-diene-3,20-dione,16,17-[butylidenebis(oxy)]-11,21-dihydroxy-, [11b,16a(R)]-;(22R)-Budesonide;Dexbudesonide;
EINECS:	257-161-7
Density:	1.27 g/cm3
Melting Point:	194-199 °C
Boiling Point:	599.7 °C at 760 mmHg
Flash Point:	201.8 °C

 

Budesonide  Introduction

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• Budesonide is a steroid that reduces inflammation in the body.
• Budesonide is used to treat mild to moderate Crohn's disease.
• Budesonide may also be used for purposes not listed in this medication guide.

How should I take budesonide

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Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take this medicine in the morning with a full glass of water.

Do not crush, chew, or break a budesonide capsule or tablet. Swallow it whole.

Your dosage needs may change if you have surgery, are ill, or are under stress. Do not change your doses or medication schedule without advice from your doctor.

Call your doctor if your symptoms do not improve, or if they get worse while using budesonide.

Budesonide can weaken your immune system. Tell your doctor if you have signs of infection such as fever, chills, body aches, vomiting, or feeling tired.

If you use this medicine long-term, you may need frequent medical tests.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

 

Budesonide Dose

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One	The recommended dose for active Crohn's disease is 9 mg once daily in the morning for up to 8 weeks.
Two	The 8 week course may be repeated for recurring episodes.
Three	The dose for maintenance of remission is 6 mg once daily for 3 months.
Four	The recommended dosage for the induction of remission in adult patients with active, mild to moderateulcerative colitis is one 9 mg extended release tablet to be taken once daily in the morning for up to 8 weeks.
Five	The recommended dose for the spray is 1 spray administered twice daily for 2 weeks followed by 1 spray once daily for 4 weeks.

 

Which drugs or supplements interact with budesonide

 

Many other drugs may interact with budesonide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

 

 

How does budesonide work

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The naturally-occurring hormone whose actions budesonide mimics, is cortisol or hydrocortisone which is produced by the adrenal glands.

Glucocorticoid steroids have potent anti-inflammatory actions. Crohn's disease is a chronic inflammatory bowel disease of unknown cause that results in diarrhea, crampy abdominal pain,fever and bleeding from the rectum.

The active ingredient in Budesonide, is released from granules in the ileum of the small intestine and the right (proximal) colon, where the inflammation of Crohn's disease occurs.

Budesonide acts directly by contact with the ileum and colon. Budesonide that is absorbed into the body travels first to the liver where it is broken-down and eliminated from the body.

This prevents the majority of the absorbed drug from being distributed to the rest of the body.

As a result, budesonide causes fewer severe side effects throughout the body than other corticosteroids.

 

Budesonide side effects

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Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• thinning skin, easy bruising, increased acne or facial hair;
• swelling in your ankles;
• weakness, tiredness, or a light-headed feeling, like you might pass out;
• nausea, vomiting, rectal bleeding;
• pain or burning when you urinate;
• menstrual problems (in women), impotence or loss of interest in sex (in men); or
• stretch marks, changes in the shape or location of body fat (especially in your face, neck, back, and waist).