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159752-10-0 IbutaMoren Mesylate MK-677
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Oral IbutaMoren Mesylate MK-677 CAS 159752-10-0 Body Building SARMS Powder Hormone
Quick detail
Ibutamoren mesylate, MK-677 | |
CAS No.: | 159752-10-0 |
Synonyms: |
Ibutamoren mesilate; Ibutamoren (Mesylate); MK-677; Ibutamoren mesylate (USAN); MK-0677; Crescendo; UNII-R90JB6QJ2B; |
Formula: | C28H40N4O8S2 |
Exact Mass: | 624.22900 |
Molecular Weight: | 624.76900 |
PSA: | 196.66000 |
LogP: | 4.97440 |
Properties |
Boiling Point: 868.9ºC at 760 mmHg |
MK-677 Description
Mk-677 is an orally administrated growth hormone secretagogue originally developed by Reverse Pharmacology. A secretagogue is the term for a substance that chemically signals for the pituitary gland to secrete growth hormone. In other words, Nutrobal could be compared to peptides like GHRP-6 or Ipamorelin, only it doesn't require any injections nor does it have any side effects like GHRP-6. This GHS (Growth Hormone Secretagogue) was developed in an aim to combat such conditions as muscle wasting, obesity and osteoporosis. It was also targeted towards treatment of elderly hip fracture patients, so there are a myriad of studies done on safety.
How MK-677 Works
MK-677 works as growth hormone pulse intensifier, which can be increase through four possible mechanisms:
1 | Increasing the release of GHRH, or “Growth Hormone Releasing Hormone” |
2 | Amplifying GHRH signaling in the somatotrophs of the anterior pituitary gland |
3 | Reducing somatostatin release, which “turns of” the release of growth hormone; |
4 | Inhibiting the signaling of the somatostatin receptor |
The incredible part being that MK-677 was found to successfully maneuver through all four of these mechanisms. Post-ingestion, growth hormone levels were shown to increase, relative to dosage, starting at 5 mg per day.
MK-677 Dosage
The most common doses of MK-677 range between 5-25mgs per day. In some cases, we’ve seen doses upwards of 50mgs per day, but these are few and far between, and didn’t result in exponential benefits above the recommended top-end dosage of 20-25mgs per day.
MK-677 Cycles
Here is an example of a Nutrobal + Cardarine + Andarine Cycle
Week | NutrobalMk-677 | CardarineGW-501516 | Anrdarine(S-4) | HCGenerate ES | N2Guard |
1 | 25mgs/ED | 20mgs/ED | 25mgs/ED | 5tabs/ED | 5caps/ED |
2 | 25mgs/ED | 20mgs/ED | 35mgs/ED | 5tabs/ED | 5caps/ED |
3 | 25mgs/ED | 20mgs/ED | 35mgs/ED | 5tabs/ED | 5caps/ED |
4 | 25mgs/ED | 20mgs/ED | 45mgs/ED | 5tabs/ED | 5caps/ED |
5 | 25mgs/ED | 20mgs/ED | 45mgs/ED | 5tabs/ED | 5caps/ED |
6 | 25mgs/ED | 20mgs/ED | 50mgs/ED | 3tabs/ED | 5caps/ED |
7 | 25mgs/ED | 20mgs/ED | 50mgs/ED | 3tabs/ED | 5caps/ED |
8 | 25mgs/ED | 20mgs/ED | 60mgs/ED | 2tabs/ED | 5caps/ED |
9 | 25mgs/ED | 20mgs/ED | 60mgs/ED | 2tabs/ED | 5caps/ED |
10 | 25mgs/ED | 20mgs/ED | 70mgs/ED | 2tabs/ED | 5caps/ED |
NOTE: Only ramp up andarine if you have the dosing schedule and side effects schedule properly planned. Otherwise, stick to a lower dose. |
MK-677 Side Effects
Some of the usual side effects that go with elevated GH levels such as numb hands, some lethargy, as well as slight increased appetite have been reported with the use of Mk-677.
Interestingly, during prolonged administration both IGF-1 and GH were increased with no increase in cortisol.
Some anecdotal evidence suggested there was a temporary small increase in prolactin when beginning administration, so individuals who are very prone to prolactin side effect may want to incorporate a short schedule of HCGenerate ES to prevent problems. I want to stress, this is only an issue for guys who are extremely prone to prolactin sides, which is usually 1% of users. How do you know if you're prone to prolactin sides If you get gynecomastia from taking trenbolone, you're prone to prolactin sides.
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