Hot Sale/High Purity 99% 1421373-66-1 in bulk supply

Min.Order / FOB Price:Get Latest Price

25 Metric Ton	FOB Price: USD 1.0000

25 Metric Ton

FOB Price: USD 1.0000

Min.Order :25 Metric Ton
Purity: 99%
Payment Terms : L/C,D/P,T/T,

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Hot Sale 1421373-66-1 High Purity 99% 1421373-66-1 1421373-66-1 in bulk supply

Quick Details

Appearance:white crystallized powder
Application: Osimertinib mesylate; AZD-9291
PackAge:25 kilogram card board barrels,lined with douclbe plastic bags
ProductionCapacity:20/30/40/50|Kilogram|Month
Storage:Dry and ventilated
Transportation:by sea or by airport

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Hot Sale/High Purity 99% 1421373-66-1 in bulk supply

AZD-9291 (Mesylate) Basic information

Product Name:	AZD-9291 (Mesylate)
Synonyms:	AZD-9291 (Mesylate);N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide methanesulfonate (1:1);AZD-9291 mesylate N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide methanesulfonate (1:1);Osimertinib mesylate;Mereletinib mesylate;Osimertinib;N-[2-(2-dimethylaminoethylmethylamino)-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide mesylate salt;Osimertinib Mesylate(AZD9291)
CAS:	1421373-66-1
MF:	C28H33N7O2.CH4O3S

Details:

Hot Sale/High Purity 99% 1421373-66-1 in bulk supply

Shanghai topchem Co., LTD and integrated high-tech enterprise composed with Production , R&D and trading , Specialized in Quinolones Api and intermediatesVeterinary drugs and suppply CMO serviece for suctomers. 1.good service, high quality with competitive price. 2.fast and safe deliver0y. 3.we have clients throughhout the world 4.exported areas: eurpore, southeast asia the middle east, south america and some other countries and areas. 5. Have our own r&d group.

What is AZD9291?

Osimertinib (previously known as mereletinib or AZD9291) is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor drug.

AZD9291 is a Kinase Inhibitor. The mechanism of action of osimertinib is as a Kinase Inhibitor, and Cytochrome P450 3A Inhibitor, and Cytochrome P450 3A4 Inducer, and Cytochrome P450 1A2 Inducer, and Breast Cancer Resistance Protein Inhibitor.

As this agent is selective towards mutant forms of EGFR, its toxicity profile may be reduced when compared to non-selective EGFR inhibitors which also inhibit wild-type EGFR.

Function of AZD9291

AZD9291 used in the therapy of selected forms of advanced non-small cell lung cancer (NSCLC). Osimertinib is associated with a moderate rate of serum aminotransferase elevations during therapy and rare instances of clinically apparent acute liver injury.

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