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Oral Active Pharmaceutical Ingredients Spironolactone 52-01-7 Used as a Diuretic

Oral Active Pharmaceutical Ingredients Spironolactone 52-01-7 Used as a Diuretic

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52-01-7 Spironolactone High Blood Pressure

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  • Appearance:white crystalline powder
  • Application:Pharmaceutical Raw Materials; Pharmaceutical Intermediate, etc
  • PackAge:100g/ bag, 2 kg/ bag, 25kg/ carton or as required
  • ProductionCapacity:10|Metric Ton|Month
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Oral Active Pharmaceutical Ingredients Spironolactone 52-01-7 Used as a Diuretic

 

Quick detail

Name: Spironolactone
CAS No.: 52-01-7
Formula: C24H32O4S
Molecular Weight: 416.62
Density: 1.24 g/cm3
Melting Point: 207-208 °C(lit.)
Boiling Point: 597 °C at 760 mmHg
Flash Point: 302.3 °C
Solubility: practically insoluble in water
Appearance: White to Off White Solid

Used as a diuretic, lactone (spironolactone), the active metabolite. Inhibition of aldosterone biosynthesis. Wow effect of blockers for Pakistan It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia.

 

Spironolactone? ?Description

Aldactone removes excess fluid from the body in congestive heart failure, cirrhosis of the liver, and kidney disease.


It also can be used in combination with other drugs to treat elevated blood pressure, and for treating diuretic-induced low potassium (hypokalemia).


Aldactone also is used to counteract the effects of excessive adrenal aldosterone production (hyperaldosteronism). Aldosterone overproduction can occur from a tumor in the adrenal gland or enlarged adrenal glands (hyperplasia of the adrenal glands).

 

Spironolactone Specification:

Ref. standard EP8/USP39
Analysis items Specification Results
Appearance white or yellowish-white powder White powder
Solubility Practically insoluble in water, soluble in ethanol(96 per cent). Complies
Identification A/B/C Meet the requirements Complies
Specific rotation

- 41 to -46°(EP) / -41 to -45°(USP)

 -43°
Loss on drying Not more than 0.5% 0.08%
Sulfated ash Not more than 0.1% 0.03%

Impurity A and Impurity C

Not more than 0.2%

 N.D

Impurity F and Impurity E

 Not more than 0.3% N.D
Impurity D Not more than 0.15% N.D
Impurity I Not more than 0.5% N.D
Other arbitrary unknown impurities Not more than 0.1% Complies
Total impurities Not more than 0.7% 0.15%
Ordinary impurities(USP) Not more than 2.0% 0.05%
Free thiol compounds(EP) Not more than 0.05 ml Complies
Free mercapto compounds(USP) Not more than 0.1ml Complies
Chromium(EP) 50ppmNot more than 50ppm Complies
Assay

97.0%~103.0%(USP) / 97.5-102%(EP)

99.9% (USP) / 100.1% (EP)
Fineness 95% Not more than 20 μm Complies
Conclusion Qualified

 

 

Side Effects of Spironolactone

  1. Vomiting, diarrhea, and stomach pain or cramps
  2. Dry mouth and thirst
  3. Dizziness, unsteadiness, and headache
  4. Gynecomastia (enlarged breast tissue) in men, and breast pain in women
  5. Irregular menstrual periods and post-menopausal vaginal bleeding
  6. Erectile dysfunction
  7. Deepening of the voice and increased hair growth
  8. Drowsiness, tiredness, and restlessness

 

Advantages:


Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.


1. Quality.Every batch of steroid powders have tobetested by our QC(quality control) before they are allowed to sell.


2. Delivery We have stock, so we can delivery quickly at the very day when receive the payment. Within 24 hours after receiving the payment Lead time 4 or 7 days.


3. Discreet package Safelyand Professionally Disguised Package Guaranteed. For your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate.


4. Warm after-sale service Any of your question would be solved for the first as soon as possible.

 

Oral Active Pharmaceutical Ingredients Spironolactone 52-01-7 Used as a Diuretic

 

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