Details
Adrenocortical Hormone Raw Materials Hydrocortisone Acetate with Strong Effect
| Product Name: | Hydrocortisone acetate |
| Synonyms: | (11beta)-21-(Acetoxy)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione;11,17-Dihydroxy-3,20-dioxopregn-4-en-21-yl acetate;11-beta,17-alpha-dihydroxy-21-acetoxypregesterone;11beta17alpha-Dihydroxy-21-acetoxypregesterone;17-alpha-hydrocorticosterone21-acetate;17alpha-Hydrocorticosterone-21-acetate;17-dihydroxy-20-dion(11-beta)-pregn-4-ene-21-(acetoxy)-11;17-dihydroxy-20-dion(11beta)-pregn-4-ene-21-(acetyloxy)-11 |
| CAS: | 50-03-3 |
| MF: | C23H32O6 |
| MW: | 404.5 |
| EINECS: | 200-004-4 |
| Product Categories: | Biochemistry;Hydroxyketosteroids;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;Veterinaries;Steroid and Hormone;Hormone Drugs;Adrenal cortical hormone drugs;API |
| Mol File: | 50-03-3.mol |
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| Hydrocortisone acetate Chemical Properties |
| Melting point | 223 °C (dec.)(lit.) |
| Fp | 223°C |
| storage temp. | 0-6°C |
| Decomposition | 223 ºC |
| Merck | 14,4787 |
| BRN | 2066841 |
| Stability: | Stable, but may be light or moisture sensitive. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 50-03-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Hydrocortisone acetate(50-03-3) |
| Safety Information |
| Hazard Codes | Xn,T |
| Risk Statements | 63-10-45 |
| Safety Statements | 36/37-45-53 |
| WGK Germany | 3 |
| RTECS | GM8960000 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| ALFA | English |
| Hydrocortisone acetate Usage And Synthesis |
| Adrenocorticotropic hormone drugs |
Hydrocortisone acetate is an adrenal hormone drugs, white crystalline powder, odorless, bitter taste. The melting point is 216 ~ 222 ℃, right optical. Slightly soluble in ethanol, ether, chloroform, acetone, insoluble in water. It was synthesized by In 17α- hydroxy progesterone. Hydrocortisone acetate has important physiological activities such as anti-inflammatory, anti-viral, anti-allergic, anti-shock, reducing inflammatory exudation effect, commonly used in clinical adrenal insufficiency and autoimmune diseases. Preparations are injection, tablets, ointments and eye drops. Adding a small amount of hydrocortisone acetate in some cosmetics cortisol can increase the efficacy of anti-allergy and improve the degree of whitening of the skin, but long-term using of such substances can cause the skin produce hormone-dependent disease. Our cosmetics cosmetics specifications prescribedthathormone substances can not be added. |
| Indications |
For allergic, non-infectious skin diseases and a number of proliferative skin disorders. Such as dermatitis, eczema, neurodermatitis, seborrheic dermatitis and itching psychosis. Figure 1 the chemical structure formula of tetra-fluoroethane. |
| Contraindications |
1. This medicine and matrix components allergy and allergic to other glucocorticoids are prohibited. 2. The primary bacterial, fungal and viral infectious skin diseases such as disabledare prohibited. The above information is edited by the chemicalbook of KuiMing. |
| Adverse Reactions | Long-term using can cause local skin atrophy, telangiectasia, pigmentation, folliculitis, perioral dermatitis and secondary infection. |
| Precautions |
1. Not long-term, large-scale use. 2. The coated parts such as a burning sensation, itching, swelling, etc., should stop the medication. |
| Chemical Property | White or almost white crystalline powder, odorless. Mp218-221.5 ℃; 25D + 166 ° (dioxane) Specific rotation [α]; ethanol maximum absorption at 240nm wavelength. Insoluble in water, slightly soluble in ethanol (1: 230) and chloroform (1: 150), insoluble in ether. |
| Uses | Corticosteroid drugs, have anti-inflammatory, anti-allergic, anti-toxins, anti-shock effect. |
| Production methods | Hydrocortisone and acetic anhydride in pyridine esterification. |
| Chemical Properties | white powder |
| Usage | Glucocorticoid |
| Hydrocortisone acetate Preparation Products And Raw materials |
| Raw materials | Azabenzene-->Hydrocortisone-->Saponin |
Package Specification: 25 Kg/Drum 10 Kg/Drum 5 Kg/Drum
Quality Specification: EP/USP/Ch.P/JP
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