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99% Dexamethasone 50-02-2 Dexamethasone
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1)Purity≥ 99%
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High Purity 99%min Corticosteroid Powder Dexamethasone CAS 50-02-2 For Anti Inflammatory
1. Description
1). Dexamethasones is a artificially synthetic glucocorticoid, belonging to a long-term glucocorticoid drugs.
Glucocorticoids can promote the metabolism of the three major nutrients while preventing protein synthesis with long-term topical being able to causing more serious consequences.
2). However, the adverse effects should be much smaller than oral medication.It is mainly used for anti-inflammatory and anti-allergy purpose which is suitable for treating rheumatoid arthritis and other collagen diseases.
3). Active Pharmaceutical Ingredients Dexamethasones is used to treat many inflammatory and autoimmune conditions , such as rheumatoid arthritis and bronchospasm . Idiopathic thrombocytopenic purpura , a decrease in numbers of platelets due to an immune problem , responds to 40 mg daily for four days ; it may be administered in 14-day cycles . It is unclear whether dexamethasones in this condition is significantly better than other glucocorticoids.
4). It is also given in small amounts before and/or after some forms of dental surgery , such as the extraction of the wisdom teeth , an operation which often leaves the patient with puffy, swollen cheeks.
2. Product Application
1). A glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase. Dexamethasones is a glucocorticoid used as an anti-inflammatory agent. Dexamethasones regulates T cell survival, growth, and differentiation. Dexamethasones inhibits the induction of nitric oxide synthase.
2). It is injected into the heel when treating plantar fasciitis, sometimes in conjunction with triamcinolone acetonide. It is useful to counteract allergic anaphylactic shock , if given in high doses.
3). It is present in certain eye drops - particularly after eye surgery - and as a nasal spray (trade name Dexacort) , and certain ear drops (Sofradex, when combined with an antibiotic and an antifungal) . Dexamethasones intravitreal steroid implants (trade name Ozurdex) have been approved by the FDA to treat ocular conditions such as diabetic macular edema , central retinal vein occlusion, and uveitis.
4). Dexamethasones is used in transvenous screw-in cardiac pacing leads to minimize the inflammatory response of the myocardium . The steroid is released into the myocardium as soon as the screw is extended and can play a significant role in minimizing the acute pacing threshold due to the reduction of inflammatory response . The typical quantity present in a lead tip is less than 1.0 mg.
5). Dexamethasones is often administered before antibiotics in cases of bacterial meningitis . It then acts to reduce the inflammatory response of the body to the bacteria killed by the antibiotics (bacterial death releases proinflammatory mediators that can cause a response which is harmful to the patient), thus improving prognosis and outcome.
COA
Test Items | Specification | Test Results | |
Appearance | white oralmost white,crystalline powder | Conform | |
Solubility | Freely soluble in water,practically insoluble or very slightly soluble in alcohol and in methylene chloride. | Conform | |
Identification | A | The UV absorption spectrum of the sample shows an absorption maximum at 276nm.The specific absorbance at the Maximum is55 to 64. | Conform |
B | Infraed absorption spectrophotometry. | Conform | |
C | Chromatogram obtained with test solution (b) is similar in position color & size to the principal spot in the chromatogram obtained with the reference solution. | Conform | |
D | An orange-red color develop in methylene chloride layer. | Conform | |
E | It geves reaction (a) of sulphates. | Conform | |
Appearance of solution | Solution S is clear and not more intensely coloured than reference solution in BY6. | Conform | |
Optical rotation | -0.10° to +0.10°determined on solution S. | +0.01° | |
Acidity or alkalinity | NMT 0.4ml of 0.01M HCL is required to change the color of the indicator to red. | Conform | |
Related substances | Impurity J ≤0.20% | Conform | |
Any other impurity ≤0.30% | Conform | ||
Total impurity ≤1.0% | Conform | ||
Boron | ≤50ppm | Conform | |
Sulphated ash | ≤0.10% | 0.06% | |
Loss on drying | ≤0.5% | 0.30% | |
Assay(on dried basis) | 98.0~101.0% | 98.8% | |
Conclusion | The test results above BP2009 |
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