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99%min Lomefloxacin Hydrochloride For Antibiotic Lomefloxacin Hydrochloride Manufacturer
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Lomefloxacin hydrochloride Basic information |
Product Name: | Lomefloxacin hydrochloride |
Synonyms: | 1,4-dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylicacimonohydrochloride;bareon;ny198;sc-47111;1-ETHYL-6,8-DIFLUORO-1,4-DIHYDRO-7-[3-METHYL-1-PIPERAZINYL]-4-OXO-3-QUINOLINECARBOXYLIC ACID HYDROCHLORIDE;LOMEFLOXACIN HCL;LOMEFLOXACIN HYDROCHLORIDE;Lomoefloxacin HCL |
CAS: | 98079-52-8 |
MF: | C17H20ClF2N3O3 |
MW: | 387.81 |
EINECS: | 1806241-263-5 |
Product Categories: | Antibiotics for Research and Experimental Use;Biochemistry;Quinolones (Antibiotics for Research and Experimental Use);Intermediates & Fine Chemicals;Pharmaceuticals;Lomefloxacin;Halogenated Heterocycles ,Benzothiazoles |
Mol File: | 98079-52-8.mol |
Lomefloxacin hydrochloride Chemical Properties |
Melting point | 290-3000C |
storage temp. | −20°C |
solubility | 1 M NaOH: soluble50mg/mL |
color | white to off-white |
Merck | 14,5562 |
CAS DataBase Reference | 98079-52-8(CAS DataBase Reference) |
Provider | Language |
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SigmaAldrich | English |
Lomefloxacin hydrochloride Usage And Synthesis |
Description | Lomefloxacin hydrochloride is the hydrochloride form of Lomefloxacin. Lomefloxacin is a bactericidal fluoroquinolone agent that is active against gram-negative and gram-positive organisms. Lomefloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited. Lomefloxacin can be used to treat many kinds of infections such as respiratory, urinary tract, obstetric, gynaecological, joint, skin, oral, ear, nose, throat and eye infections. Compared with other quinolone antibacterial drugs, lomefloxacin has certain advantages such as convenient administration and no necessity of theophylline dosage adjustment. |
Chemical Properties | White powder with no smell, bitter taste |
Uses | Fluorinated quinolone antibacterial. DNA gyrase antagonist |
Definition | ChEBI: The hydrochloride salt of lomefloxacin. It is administered by mouth to treat bacterial infections including bronchitis and urinary tract infections. It is also used topically as eye drops for the treatment of bacterial conjunctivitis, and as ear drops for he treatment of otitis externa and otitis media. |
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