99%min Darunavir 20...

99%min Darunavir 206361-99-1

99%min Darunavir 206361-99-1

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10 Gram

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  • Min.Order :10 Gram
  • Purity: 99%min
  • Payment Terms : T/T,

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99%min Darunavir Darunavir Manufacturer For Antibiotic

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  • Appearance:White Powder
  • Application:For Pharmaceutical Raw Materials
  • PackAge:100g/ bag, 2 kg/ bag, 25kg/ carton or as required
  • ProductionCapacity:1000|Metric Ton|Month
  • Storage:Dry and cool place
  • Transportation:By DHL, TNT, FedEx, HKEMS, UPS, Etc

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Darunavir Basic information
AIDS treatment
Product Name: Darunavir
Synonyms: [(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenyl-methyl)propyl]carabamic Acid (3R,3aS,6aR)-Hexahydrofuro[2,3-b]-furan-3-yl Ester;Darunavir;TMC-114;UIC-94017;[(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenyl-methyl)propyl]carabamic Acid (3R,3aS,6aR)-Hexahydrofuro[2,3-β]-furan-3-yl Ester;[(3R,3aS,6aR)-2,3,3a,4,5,6a-Hexahydrofuro[5,4-b]furan-3-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate;D03656;Darunavir (usan/inn)
CAS: 206361-99-1
MF: C27H37N3O7S
MW: 547.66
EINECS: 1592732-453-0
Product Categories: Antiviral Agents;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics;Heterocycles;Inhibitors;peptides
Mol File: 206361-99-1.mol
Darunavir Structure
 
Darunavir Chemical Properties
Melting point  74-760C
storage temp.  -20°C Freezer
 
 
Darunavir Usage And Synthesis
AIDS treatment Darunavir is a new kind of non peptide anti retroviral protease inhibitors in AIDS therapy. It is first developed by the Johnson pharmaceutical Iceland branch, Tibotec. It is of the highest bioavailability in the 6 protease inhibitors (saquinavir, ritonavirvir, indinavir, naphthalene nelfinavir, amprenavir and ABT378/r). It acts by blocking the formation of new and mature virus particles from the surface of the infected host cells and inhibiting the virus's protease. When the product is used for a long time, it usually can reduce the HIV virus vector in blood, increase the count of CD4 cells, reduce the chance of HIV infection, improve the quality of life and prolong life. It is suitable for adults who are infected with the HIV virus but have no effect on the use of existing antiretroviral drugs. The drug must be combined with the use of low doses of ritonavir or other antiretroviral agents, in order to improve the efficacy. The antiviral activity in vitro can be evaluated by being against acute and chronic infected lymphocytes and lymphocytes in peripheral blood. The IC50 is 0.012 to 0.08 mmol/ L for acute infected cells and 0.41 mmol/L for chronic infected cells. For oral administration, recommended dose is 1,200mg once and twice per day. The doseshould be reduced for patients with mild to moderate liver dysfunction and those with renal dysfunction. The adverse reaction of darunavir is mainly gastrointestinal reaction, flushing, itching and perioral numbness, depression, mood disorders, taste disorder etc. This product is not recommended for patients with moderate to severe liver dysfunction. Because of the sulfonamides in this component, it is prohibited for those who are allergic to sulfanilamide and any component in the prescription of this product.
Chemical Properties White Amorphous Solid
Uses Second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral
Definition ChEBI: An N,N-disubstituted benzenesulfonamide bearing an unsubstituted amino group at the 4-position, used for the treatment of HIV infection. A second-generation HIV protease inhibitor, darunavir was designed to form robust interactions with the protease enzyme from many strains of HIV, including those from treatment-experienced patients with multiple resistance mutations to other protease inhibitors.

 

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