99%min Aprepitant 1...

99%min Aprepitant 170729-80-3

99%min Aprepitant 170729-80-3

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10 Gram

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  • Min.Order :10 Gram
  • Purity: 99%min
  • Payment Terms : T/T,

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99%min Aprepitant Aprepitant Manufacturer For Chemotherapy Vomiting Medicine

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  • Appearance:White Powder
  • Application:For Pharmaceutical Raw Materials
  • PackAge:100g/ bag, 2 kg/ bag, 25kg/ carton or as required
  • ProductionCapacity:1000|Metric Ton|Month
  • Storage:Dry and cool place
  • Transportation:By DHL, TNT, FedEx, HKEMS, UPS, Etc

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Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.


1. Quality.Every batch of steroid powders have tobetested by our QC(quality control) before they are allowed to sell.


2 . Delivery We have stock, so we can delivery quickly at the very day when receive the payment. Within 24 hours after receiving the payment Lead time 4 or 7 days.


3 . Discreet package Safelyand Professionally Disguised Package Guaranteed. For your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate

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Details:

Aprepitant Basic information
Anti-Vomiting drug during chemotherapy Dose and usage Side effects Uses
Product Name: Aprepitant
Synonyms: aprepitant;5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,;5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one, Emend;5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one;Emend;MK-0869;Aprepitant(MK-0869);ONO 7436
CAS: 170729-80-3
MF: C23H21F7N4O3
MW: 534.4266624
EINECS: 1806241-263-5
Product Categories: Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate;Aprepitant;Inhibitors
Mol File: 170729-80-3.mol
Aprepitant Structure
 
Aprepitant Chemical Properties
Melting point  244-246°C
alpha  D25 +69° (c = 1.00 in methanol)
storage temp.  -20°C Freezer
CAS DataBase Reference 170729-80-3(CAS DataBase Reference)
Description Aprepitant is an antiemetic chemical compound that belongs to “substance P” antagonists (SPA) with its effect being blocking the neurokinin 1(Nk1) receptor. It is used for the prevention of acute and delayedchemotherapy-induced nausea and vomiting(CINV) and for prevention ofpostoperative nausea and vomiting. It can also be used for the treatment of cyclic vomiting syndrome and late-stage chemotherapy induced vomiting occurring during cancer treatment. Aprepitant alleviates the case of vomiting in patients through balking the signals released by Nk1 receptors. Nk1 is a G-protein-coupled receptor with its ligand being substance P (SP). The high concentration of SP is required for the vomiting reflex. Aprepitant blocks the process of SP-NK1 signaling in activating the vomiting reflex. 
Chemical Properties Off-White to Light Yellow Cyrstalline Solid
Uses A novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.
Uses anticholinergic
Uses Antineoplastic drug.

 

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