Factory Supply 99% ...

Factory Supply 99% Pharmaceutical Grade Antihypertensive Drugs Indapamide CAS NO.26807-65-8
Factory Supply 99% Pharmaceutical Grade Antihypertensive Drugs Indapamide CAS NO.26807-65-8
Factory Supply 99% Pharmaceutical Grade Antihypertensive Drugs Indapamide CAS NO.26807-65-8
Factory Supply 99% Pharmaceutical Grade Antihypertensive Drugs Indapamide CAS NO.26807-65-8
Factory Supply 99% Pharmaceutical Grade Antihypertensive Drugs Indapamide CAS NO.26807-65-8

Factory Supply 99% Pharmaceutical Grade Antihypertensive Drugs Indapamide CAS NO.26807-65-8

Min.Order / FOB Price:Get Latest Price

1 Gram

FOB Price: USD 1.0000

  • Min.Order :1 Gram
  • Purity: 99% min
  • Payment Terms : T/T,

Keywords

Indapamide 26807-65-8 Indapamide powder

Quick Details

  • Appearance:White crystallized powder
  • Application:medical intermediate,sex enhancement, muscle shaping
  • PackAge:al foil bag
  • ProductionCapacity:1000|Kilogram|Month
  • Storage: Kept in a well-closed, light-resistant, dry and cool place
  • Transportation: Kept in a well-closed, light-resistant, dry and cool place

Superiority:

1, High quality with competitive price: 
1)Purity≥ 99% 
2)We are manufacturer and can provide high quality products with factory price,offering free samples to test, a few shipping fee only.

 

2.Flexible Payment term
1).we accept every payment term as if you could imagine,such as T/T, Paypal, Money Gram, , Bank transfer.
2).we also offer Bitcoin as a payment to your honor.like Australia,Canada.

 

3, Fast and safe delivery 
1)Parcel can be sent out in 24 hours after payment. Tracking numbers available 
3)Secure and discreet shipment. Various transportation methods for your choice.
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring. 
5)We have special way could ship 0.01kg to sveral kg products a time. We offer melting powder into liquid service. And ship the liquid in special bottles.
6)Offer the latest tracking number for you to check

 

4, We have clients throughout the world. 
1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire. 
2)Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility. 
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.

 

5. Good after-sales service.
1)Tell the package update ASAP, and will try best solve when customer encountered various problems.
2)we will teach you recipes and instructions for all kind of steroid to turn powder into liquid, and liquid become sterile ones.

 

Details:

Details

 

99% Pharmaceutical Grade Antihypertensive Drugs Indapamide 



Product Name: Indapamide
Synonyms:1-(4-chloro-3-sulfamoylbenzamido)-2-methylindoline;3-(aminosulfonyl)-4-chloro-n-(2,3-dihydro-2-methyl-1h-indol-1-yl)-benzamid;4-chloro-n-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide
CAS:26807-65-8
MF:C16H16ClN3O3S
MW:365.83
EINECS:248-012-7

Indapamide Chemical Properties

Chemical Properties White Crystalline Solid
Melting point 160-162°C
Water Solubility Soluble in ethanol. Insoluble in water


Indapamide Usage And Synthesis

Uses Used as an antihypertensive. Diuretic
Definition ChEBI: A sulfonamide formed by condensation of the carboxylic group of 4-chloro-3-sulfamoylbenzoic acid with the amino group of 2-methyl-2,3-dihydro-1H-indol-1-amine.

Diuretic Antihypertensive Drug 

White needle crystal or crystalline powder, odorless, tasteless. It is almost insoluble in water or dilute hydrochloric acid, while it can be dissolved in ethanol or ethyl acetate, and it is soluble in acetone, acetic acid, slightly soluble in chloroform or ether. 
Indapamide is currently the most popular non-prescription diuretic antihypertensive drug with good efficacy, stable blood pressure, fewer side effects, etc. It was originally developed for the first time by the French Servier (Servier) pharmaceutical company. Indapamide film-coated tablets were first successfully developed by Tianjin Lisheng pharmaceutical company in 1988 in China. The trade name is "life than the mountains." In the mid-1990s, Zhejiang Apeloa pharmaceutical, Yantai Xiyuan pharmaceutical factory, Zhejiang East medicine, Dongguan million into pharmaceuticals, Shanxi Asia-medicine, medicine Fuxin Shibata, Puyang the yuan Pharmaceutical, Chongqing Friends of pharmaceutical drugs, 8 pharmaceutical formulations were approved for production. In the late 1990s, the French pharmaceutical company Servier took indapamide sustained-release tablets into China. The trade name is "Na Ionizers." Subsequently, indapamide raw material drug localization has been progress. Currently, seven companies have been allowed to produce raw material drug types. 
Indapamide have diuretic and calcium antagonist dual effect by inhibiting the proximal end of the distal convoluted tubule Na+ reabsorption, resulting in diuresis, while by blocking Ca2+ influx especially a higher selectivity for vascular smooth muscle to dilate the small blood vessels of the outer periphery, resulting in antihypertensive effect. But the effect to vascular smooth muscle is stronger than the diuretic effect. It can lower blood pressure with lower dose compared to diuretic effect. Higher dose will display diuretic effect. But there is no disadvantage compared to thiazide diuretics, that it does not cause orthostatic hypotension, flushing and reflex tachycardia, nor blood lipids, glucose metabolism and renal function. The therapeutic dosage for heart rate, cardiac output, electrocardiogram are no significant change, as well as for the central nervous system and autonomic. There is antihypertensive effect by oral for 2~3h, maintaining 24h. single medication has good effect. Diuretic effect appears at 3h, achieving maximum effect for 4~6h. It is different from other diuretics. This product is fat-soluble. After oral administration, there is highest concentration in the liver, renal plasma, and lower concentration in heart, lung, muscle, fat. This product excretes from the kidney mainly by metabolites and 5% of the prototype. Indapamide is for mild to moderate hypertension, and for sodium retention caused by congestive heart failure. It is also applied to hypertension with renal failure, diabetes mellitus, high blood lipids. Single medication has significant effect. It is combined with β-receptor blockers that has better effect. Because the drug has a diuretic effect, it can cause hypokalemia, which can add potassium.

COA

TEST STANDARD RESULTS
1.CHARACTERS WHITE TO OFF-WHITE, CRYSTALLINE POWDER.SOLUBLE IN METHANOL,
IN ALCOHOL,IN ACETONITRILE,IN GLACIAL ACETIC ACID,AND IN ETHYL
ACETATE;VERY SLIGHTLY SOLUBLE IN ETHER AND IN CHLOROFORM;
PRACTICALLY INSOLUBLE IN WATER.
CONFORMS
2.IDENTIFICATION 1.INFRARED ABSORPTION CONFORMS
1.ULTRAVIOLET ABSORPTION CONFORMS
3.LOSS ON DRYING ≤3.0% 2.0%
4.OVIS MEETS THE REQUIREMENTS CONFORMS
5.RESIDUE ON IGNITION ≤0.1% CONFORMS
6.CHROMATOGRAPHIC PURITY(TLC) SINGLE IMPURITY≤0.5% CONFORMS
7.ASSAY (ON THE DRIED BASIS) 98.0-101.0% 100.3%
CONCLUSION: ALL THE ITEMS CONFORM TO THE SPECIFICATION OF USP33.
 

 

 

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