99% Tacrolimus 1049...

99% Tacrolimus 104987-11-3 Macrolide Antibiotics

99% Tacrolimus 104987-11-3 Macrolide Antibiotics

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10 Gram

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  • Min.Order :10 Gram
  • Purity: 99%
  • Payment Terms : T/T,

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99% Tacrolimus Tacrolimus Manufacturer Macrolide Antibiotics

Quick Details

  • Appearance:White Powder
  • Application: It Can Be Used As Pharmaceutical Intermediates, Or As Curing Agent Of Epoxy Resins, Etc
  • PackAge:100g/ bag, 2 kg/ bag, 25kg/ carton or as required
  • ProductionCapacity:10000|Metric Ton|Month
  • Storage:Store in sealed containers at cool & dry place. Protect from light, moisture and pest infestation.
  • Transportation:By DHL, TNT, FedEx, HKEMS, UPS, Etc

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Advantages:
 
Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.

 

1. Quality.Every batch of steroid powders have tobetested by our QC(quality control) before they are allowed to sell.


2. Delivery We have stock, so we can delivery quickly at the very day when receive the payment. Within 24 hours after receiving the payment Lead time 4 or 7 days.


3. Discreet package Safelyand Professionally Disguised Package Guaranteed. For your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate.


4. Warm after-sale service Any of your question would be solved for the first as soon as possible.

 

Details:

Tacrolimus Basic information
Product Name: Tacrolimus
Synonyms: (2-propenyl)-,(3s-(3r*(e(1s*,3s*,4s*)),4s*,5r*,8s*,9e,12r*,14r*,15s*,16r*,18s*;,19s*,26ar*))-;16-dimethoxy-4,10,12,18-tetramethyl-8-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1;19-epoxy-3h-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4h,23h)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-14,16-dim;6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-5;fr900506;prograf;tsukubaenolide
CAS: 104987-11-3
MF: C44H69NO12
MW: 804.02
EINECS: 1308068-626-2
Product Categories: Active Pharmaceutical Ingredients;Immunosuppressant.;Intermediates & Fine Chemicals;Pharmaceuticals;API;Chiral Reagents;Fujimycin, Prograf;antibiotic;Inhibitors
Mol File: 104987-11-3.mol
Tacrolimus Structure
 
Tacrolimus Chemical Properties
Melting point  113-115°C
Fp  2℃
storage temp.  −20°C
solubility  DMSO: >3 mg/mL
form  solid
color  white
Water Solubility  Freely soluble in DMSO or ethanol. Poorly soluble in water.Soluble in dimethyl sulfoxide, ethanol, water, acetone, chloroform, ethyl acetate, ether, methanol and dimethyl formamide.
CAS DataBase Reference 104987-11-3(CAS DataBase Reference)
 
Safety Information
Hazard Codes  T,Xi,Xn,F
Risk Statements  25-36/37/38-36-20/21/22-11
Safety Statements  45-36-26-36/37-16-60-20
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  KD4201200
HazardClass  6.1
 
Tacrolimus Usage And Synthesis
Chemical Properties White Crystalline Solid
Uses An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.
Uses FK-506 (Tacrolimus) is a macrolide immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system
Uses Tacrolimus (fujimycin) was discovered as a potent inhibitor of IL2 production in a targeted search for novel immunosuppressants. Tacrolimus acts by blocking T cell proliferation in vitro by inhibiting the generation of several lymphokines, notably the original target IL-2. Tacrolimus inhibits the activity of FK-506 binding protein, Ca2+-dependent phosphatase and calcineurin, and activates NF-κB through phosphorylation and degradation of IκBα.
Uses treatment of Cushing's syndrome
Uses For use after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It was first approved by the FDA in 1994 for use in liver transplantation, this has been extended to include kidney, heart,
Definition ChEBI: Tacrolimus is a macrolide containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis.

 

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