Best price Nilotini...

Best price Nilotinib 641571-10-0 certified factory with fast delivery
Best price Nilotinib 641571-10-0 certified factory with fast delivery
Best price Nilotinib 641571-10-0 certified factory with fast delivery
Best price Nilotinib 641571-10-0 certified factory with fast delivery
Best price Nilotinib 641571-10-0 certified factory with fast delivery

Best price Nilotinib 641571-10-0 certified factory with fast delivery

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1 Gram

FOB Price: USD 1.0000

  • Min.Order :1 Gram
  • Purity: 99% min
  • Payment Terms : T/T,

Keywords

Erlotinib 183321-74-6 Nilotinib factory

Quick Details

  • Appearance:White crystallized powder
  • Application:medical
  • PackAge:al foil bag
  • ProductionCapacity:1000|Kilogram|Month
  • Storage: Kept in a well-closed, light-resistant, dry and cool place
  • Transportation: Kept in a well-closed, light-resistant, dry and cool place

Superiority:

1, High quality with competitive price: 
1)Purity≥ 99% 
2)We are manufacturer and can provide high quality products with factory price,offering free samples to test, a few shipping fee only.

 

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1).we accept every payment term as if you could imagine,such as T/T, Paypal, Money Gram, , Bank transfer.
2).we also offer Bitcoin as a payment to your honor.like Australia,Canada.

 

3, Fast and safe delivery 
1)Parcel can be sent out in 24 hours after payment. Tracking numbers available 
3)Secure and discreet shipment. Various transportation methods for your choice.
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring. 
5)We have special way could ship 0.01kg to sveral kg products a time. We offer melting powder into liquid service. And ship the liquid in special bottles.
6)Offer the latest tracking number for you to check

 

4, We have clients throughout the world. 
1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire. 
2)Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility. 
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.

 

5. Good after-sales service.
1)Tell the package update ASAP, and will try best solve when customer encountered various problems.
2)we will teach you recipes and instructions for all kind of steroid to turn powder into liquid, and liquid become sterile ones.

 

Details:

Details

Best price Nilotinib 641571-10-0 certified factory with fast delivery

 


	

 

Quick Details:

Product Name

Nilotinib

Molecular Formula

C28H22F3N7O

Molecular Weight

529.53

Storage

3years in -20ºC

Targets

Bcr-Abl

IC50

30 nM

IC50

/

Dosage

Oral administration, 75 mg/kg, daily

Product Name: Nilotinib

Other Name:Nilotinib;AMN 107;Benzamide, 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-;4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4 -pyridin-3-ylpyrimidin-2-yl)amino]benzamide;Nilotinib(TINIBS );4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide;Nilotinib for research;Tasigna

Model No.: ATC-142

CAS No.: 641571-10-0

Molecular Formula: C28H22F3N7O

Molecular Weight:529.52

Stability: N/A

Target:N/A

Appearance: Off-White Solid

Melting Point: N/A

Purity: 99%+

Suitable People: ALl

Product Specifications: Pharmaceutical Grade

Standard: Qualified

MOQ(Minimum Order Quantity): 10g

Payment: L/C, T/T,

Shipment: EMS, DHL, FedEx, TNT

Packing: Aluminium Foil Bag or as Required

Brand: Biocar

Origion: Hubei,China

Export Markets: Global

 

Product Description

Nilotinib is a selective, oral inhibitor of tyrosine kinase with IC50 values of 20, 42, 31, 38, 29 and 41 nM for the autophosphorylation of native BCR-ABL (WT p210) and mutant BCR-ABL (E281K, E292K, F317L, M351T and F486S), respectively.

Nilotinib was designed based on the structure of imatinib and showed the superiority over imatinib in newly diagnosed or imatinib-resistant chronic myelogenous leukemia (CML). It was more potent than imatinib to wild-type BCR-ABL in a wide range of CML-derived and transfected cell lines. Nilotinib was also efficacious in gastrointestinal stromal tumors. Nilotinib showed inhibition activities in KIT mutant cells, including KITV560del, KITK642E and KITV560G (IC50 value of 108 nM). It also was effect to double mutations of KIT, such as KITV560del/V654A, KITV559D/D820Y, KITV560del/V654A (IC50: 192 nM) and KITV559D/D820Y (IC50: 297 nM). Besides that, Nilotinib exerted selective inhibition of PDGFRα and PDGFRβ. It suppressed cell proliferation with IC50 value of 0.54 nM in EOL-1 cells with constitutive activation of FIP1L1-PDGFRα.

Nilotinib is an anti-cancer medication that is used to treat some types of leukemia, specifically Philadelphia chromosome positive chronic myeloid leukemia (Ph + CML). This medication is called a kinase inhibitor, which means that it works to halt the growth and spread of cancer cells. Nilotinib accomplishes this by inhibiting an abnormal protein that is responsible for instructing cancer cells to multiply. With this particular type of cancer, the body manufactures a great deal of abnormal white blood cells. Nilotinib is only prescribed after other cancer treatments, such as imatinib, have been tried and have not been sufficient.

Nilotinib (AMN107, trade name Tasigna), in the form of the hydrochloride monohydrate salt, is a small-molecule tyrosine kinase inhibitor approved for the treatment of imatinib-resistant chronic myelogenous leukemia. Structurally related to imatinib, it was developed based on the structure of the Abl-imatinib complex to address imatinib intolerance and resistance. Nilotinib is a selective Bcr-Abl kinase inhibitor that is 10-30 fold more potent than imatinib in inhibiting Bcr-Abl tyrosine kinase activity and proliferation of Bcr-Abl expressing cells.

 
 

 

Description:

 

This peptide hormone, called alpha-Melanocyte stimulating hormone or MSH, activates certain melanocortin receptors in the process of exerting its effects. Indeed, MSH also exerts potent influence over lipid metabolism, appetite, and sexual libido via these melanocortin receptors. As a result, Melanotan 2 has been shown in studies to exhibit appetite suppressant, lipolytic, and libido-enhancing effects in addition to promoting skin tanning.

 

Applications:


Testosterone Acetate combination of Testosterone and ester acetate, Testosterone Acetate is an androgenic steroide with a pronounced anabolic effect. Most acetate treatments deliver medication to the body relatively quickly.

Testosterone Acetate has very low risk of water retention. Individuals that utilize this form of Testosterone also claim that it is arguably the most painless form of Testosterone. Testosterone Acetate ester is much faster acting, and thus requires a more frequent schedule in order to keep blood levels as stable as possible.

 

Testosterone Acetate Results of Analysis:

 

Test Items

Specification

Test Results

Appearance

White or almost white crystalline powder

white crystalline powder

Loss on drying

≦0.5%

0.34%

Melting point

139-141 °C

139-140 °C

(HPLC)Assay

97-103.0%

99.08%

Free acid

0.5%max

0.31%

Conclusion

The aboye product conforms analysis standard

Conform

 

 

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