CasNo.1454846-35-5,PF-06463922,(1454846-35-5) Suppliers

1 Metric Ton	Negotiable

Min.Order :1 Metric Ton
Purity: 99%
Payment Terms : L/C,T/T

Keywords

PF-06463922;(10R)-7-Amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile PF-06463922, Lorlatinib;(R)-26-amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile Lorlatinib,PF-06463922;EOS-60936

Quick Details

Appearance:
Application:pharmaceutical intermediate
PackAge:according to client's requirments
ProductionCapacity:|Metric Ton|Day
Storage:
Transportation:BY AIR, BY SEA

Superiority:

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Details:

PF-06463922 Usage And Synthesis Uses Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that promotes cell proliferation and blocks apoptosis. PF-06463922 is an ATP-competitive, selective inhibitor of ALK (Ki = < 0.07 nM) and c-Ros oncogene 1 (ROS1, Ki = 0.7 nM). It has strong activity against all known ALK and ROS1 mutants identified in patients, including the EML4-L1196M mutant of ALK (Ki = < 0.02 nM). PF-06463922 is orally available, displaying inhibition of ALK phosphorylation and antitumor efficacy in a xenograft model expressing EML4-L1196M ALK. It demonstrates efficient blood-brain barrier penetration, produces brain tumor regression in mice harboring EML4-ALK tumors, and increases overall survival.[Cayman Chemical]