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99% Doxorubicin Hydrochloride Doxorubicin Hydrochloride Manufacturer Anti-tumor Drugs
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Doxorubicin hydrochloride Basic information |
Product Name: | Doxorubicin hydrochloride |
Synonyms: | ADRIACIN;ADRIBLASTINA;ADRIBLASTINA HYDROCHLORIDE;ADRIAMYCIN HCL;ADRIAMYCIN HYDROCHLORIDE;(8s-cis)-10-[(3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride;14-HYDROXYDAUNOMYCIN HCL;14-HYDROXYDAUNOMYCIN HYDROCHLORIDE |
CAS: | 25316-40-9 |
MF: | C27H30ClNO11 |
MW: | 579.98 |
EINECS: | 246-818-3 |
Product Categories: | APIs;Active Pharmaceutical Ingredients;API;Intermediates & Fine Chemicals;Pharmaceuticals;Antitumour;Adriamycin;inhibitor;Anti-cancer&immunity;Inhibitors |
Mol File: | 25316-40-9.mol |
Doxorubicin hydrochloride Chemical Properties |
Melting point | 216 °C (dec.)(lit.) |
alpha | D20 +248±2° (c = 0.1 in methanol) |
storage temp. | 2-8°C |
solubility | H2O: 10 mg/mL, clear, red-orange |
color | orange to dark red |
Water Solubility | Soluble in water. |
λmax | 497nm(H2O)(lit.) |
Merck | 14,3439 |
InChIKey | MWWSFMDVAYGXBV-RUELKSSGSA-N |
CAS DataBase Reference | 25316-40-9(CAS DataBase Reference) |
EPA Substance Registry System | 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-. alpha.-L-lyxo-hexopyranosyl) oxy]-7,8,9,10-tetrahydro- 6,8,11-trihydroxy-8-(hydroxyacetyl)- 1-methoxy-, hydrochloride, (8S,10S)-(25316-40-9) |
Safety Information |
Hazard Codes | T,T+,Xi |
Risk Statements | 45-22-40-26/27/28-36/38 |
Safety Statements | 53-45-36/37/39-22-7/9 |
WGK Germany | 3 |
RTECS | QI9295900 |
F | 10-21 |
HS Code | 29419090 |
Doxorubicin hydrochloride Usage And Synthesis |
Chemical Properties | Orange-Red Crystalline Solid |
Uses | Used as an antineoplastic |
Uses | Strong fluorescent dye intercalating into DNA. Antitumour antibiotic. Effect of adriamycin on heart mitochondrial DNA. Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent. |
Uses | Antibacterial;DNA intercalant |
Uses | Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumour agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems the free base and salt may behave differently. |
Uses | Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumor agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems the free base and salt may behave differently. |
Uses | Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.[Cayman Chemical] |
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