99% Oxaliplatin CAS: 61825-94-3

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10 Gram	Negotiable

10 Gram

Negotiable

Min.Order :10 Gram
Purity: 99%
Payment Terms : T/T,,MoneyGram

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99% Oxaliplatin Oxaliplatin Manufacturer For Anti-tumor Drugs

Quick Details

Appearance:White Powder
Application: It Can Be Used As Pharmaceutical Intermediates, Or As Curing Agent Of Epoxy Resins, Etc
PackAge:100g/ bag, 2 kg/ bag, 25kg/ carton or as required
ProductionCapacity:10000|Metric Ton|Month
Storage:Store in sealed containers at cool & dry place. Protect from light, moisture and pest infestation.
Transportation:By DHL, TNT, FedEx, HKEMS, UPS, Etc

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Advantages:

Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.

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Details:

Oxaliplatin Basic information

Indications and Usage Mechanisms of Action Adverse Effects

Product Name:	Oxaliplatin
Synonyms:	[SP-4-2-(1R-TRANS)]-(1,2-CYCLOHEXANEDIAMINE-N,N')[ETHANEDIOATA(2-)-O,O']PLATINUM;OXALIPLATIN;trans-l-diaminocyclohexane oxalatoplatinum;(1,2-cyclohexanediamine-n,n’)(ethanedioato(2-)-o,o’)-platinu(sp-4-2-(1r-tr;1-ohp;oxalato(1r,2r-cyclohexanediammine)platinum(ii);oxalatoplatin;oxalatoplatinum
CAS:	61825-94-3
MF:	C8H14N2O4Pt
MW:	397.29
EINECS:	274-613-9
Product Categories:	Pharmaceutical material and intermeidates;Active Pharmaceutical Ingredients;Antineoplastic;Intermediates & Fine Chemicals;Pharmaceuticals;APIs;Amines;Heterocycles;chemical reaction,pharm,electronic,materials;PRAXILENE;Inhibitors
Mol File:	61825-94-3.mol

Oxaliplatin Chemical Properties

storage temp.	Store at +4°C
form	solid
Water Solubility	Soluble in water with heating and/or sonication
Merck	14,6912
Stability:	Stable. Store cool. Incompatible with oxidizing agents.
InChIKey	ZROHGHOFXNOHSO-BNTLRKBRSA-L

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	36/37/38-40-42/43
Safety Statements	26-36
RIDADR	2811
WGK Germany	3
RTECS	TP2275850
HazardClass	6.1(a)
PackingGroup	II

Oxaliplatin Usage And Synthesis

Indications and Usage	Oxaliplatin, also called Eloxatin or Eloxatine, is a platinum derivative. Used clinically to treat patients with metastatic colorectal cancer after failure of fluorouracil treatment, can be used alone or in combination with 5-fluorouracil. It is the third-generation platinum antitumor compound after cisplatin and carboplatin, and so far the only platinum-based drug with significant effectiveness against colorectal cancer. It also inhibits proliferation of ovarian cancer and melanoma cell lines.
Mechanisms of Action	Acts on DNA through production of alkylating conjugates, inhibiting its synthesis and reproduction by forming interchain and intrachain cross-links.
Adverse Effects	Hematopoietec system: Oxaliplatin has a certain blood toxicity. When used alone, it can cause the following adverse effects: anemia, leukopenia, neutropenia, thrombocytopenia, sometimes reaching grade 3 or 4. Increases hematologic toxicities such as neutropenia and thrombocytopenia when combined with 5-fluorouracil. Digestive system: can cause nausea, vomiting, and diarrhea when used alone. These symptoms can sometimes be very serious. These side effects are significantly exacerbated when used in combination with 5-fluorouacil. Use of prophylactic and/or therapeutic antiemetic drugs is recommended. Nervous system: Peripheral sensory neuropathy characterized by peripheral neuritis. Sometimes associated with convulsions and sensory disturbances in the mouth, upper respiratory tract, and upper GI tract.
Chemical Properties	White Crystalline Solid
Uses	A antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA
Uses	Third generation platinum complex. An antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA. Antineoplastic.
Uses	vasodilator
Uses	A potent anti-neoplastic agent that binds to DNA and shows efficacy in Cisplatin resistant cell lines
Uses	Oxaliplatin is a platinum-based antineoplastic agent that functions by forming DNA adducts specifically in cancer cells, preventing DNA replication and transcription which leads to cell death. Oxaliplatin has cytotoxic effects in a broad range of cell lines, including colon, ovarian, and lung cancer, with IC50 values ranging from 0.5-240, 0.12-19.8, and 2.6-6.1 μM, respectively. Through its general cytotoxic effects, oxaliplatin has anti-tumor activity against advanced colorectal cancer and is typically administered with fluorouracil and leucovorin in a combination known as FOLFOX.

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