Isoamyl Nitrite Manufacturer 110-46-3 For Anti-angina Drugs

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10 Gram	Negotiable

10 Gram

Negotiable

Min.Order :10 Gram
Purity: 99%
Payment Terms : T/T,

Keywords

99% Isoamyl Nitrite Isoamyl Nitrite Manufacturer For Anti-angina Drugs

Quick Details

Appearance:White Powder
Application: It Can Be Used As Pharmaceutical Intermediates, Or As Curing Agent Of Epoxy Resins, Etc
PackAge:100g/ bag, 2 kg/ bag, 25kg/ carton or as required
ProductionCapacity:10000|Metric Ton|Month
Storage:Store in sealed containers at cool & dry place. Protect from light, moisture and pest infestation.
Transportation:By DHL, TNT, FedEx, HKEMS, UPS, Etc

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Advantages:

Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.

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Isoamyl nitrite Basic information

Antianginal drugs Cyanide poisoning antidote Chemical Properties Uses Production method Category Toxicity grading Acute toxicity Explosive hazardous characteristics Flammability hazard characteristics Storage characteristics Extinguishing agent

Product Name:	Isoamyl nitrite
Synonyms:	Isoamyl nitrite,97%,stabilized;IsoaMyl nitrite, stabilized, 90% 100GR;IsoaMyl nitrite, 96%, stabilized;ISOPENTYL NITRITE EXTRA PURE STABILIZED;Nitrite isoaMyl acetate (110-46-3) - 2;sopentyl nitrite;Isoamyl nitrite 3-Methylbutyl Nitrite;Isopentyl nitrite, stabilized with 0.2% anhyd. sodium carbonate
CAS:	110-46-3
MF:	C5H11NO2
MW:	117.15
EINECS:	203-770-8
Product Categories:	Organics
Mol File:	110-46-3.mol

Isoamyl nitrite Chemical Properties

Boiling point	99 °C(lit.)
density	0.872 g/mL at 25 °C(lit.)
refractive index	n20/D 1.386(lit.)
Fp	50 °F
storage temp.	2-8°C
form	Liquid
color	Clear yellow
Water Solubility	<0.01 g/100 mL at 18 ºC
Sensitive	Air & Light Sensitive
Merck	14,5123
BRN	969510
Stability:	Stability Unstable. Air and light sensitive. Flammable. Forms explosive mixtures with air or oxygen. Incompatible with oxidizing agents, reducing agents.
InChIKey	OWFXIOWLTKNBAP-UHFFFAOYSA-N
CAS DataBase Reference	110-46-3(CAS DataBase Reference)
NIST Chemistry Reference	Amyl Nitrite(110-46-3)
EPA Substance Registry System	Nitrous acid, 3-methylbutyl ester(110-46-3)

Safety Information

Hazard Codes	F,Xn
Risk Statements	11-20/22
Safety Statements	16-24-46
RIDADR	UN 1113 3/PG 2
WGK Germany	1
RTECS	NT0187500
F	1-8-9
TSCA	Yes
HazardClass	3
PackingGroup	II
Hazardous Substances Data	110-46-3(Hazardous Substances Data)

Isoamyl nitrite Usage And Synthesis

Antianginal drugs	Light yellow transparent liquid, ether-like smell with fruity. It volatiles at room temperature, and is easy to burn. It is insoluble in water, can be mixed with alcohol, ether, chloroform or benzene arbitrary at any ratio. In case of light and air it will break down. Isoamyl nitrite, also known as amyl nitrite, is the fastest onset, and the shortest duration of anti-anginal drugs, is a sub-short-acting nitrates vasodilator, its pharmacological effects is similar to nitroglycerin, it can directly relax vascular smooth muscle, especially for small vascular smooth muscle, make systemic vasodilation, reduce peripheral resistance, blood pressure, reduce venous return blood, reduce cardiac output, thereby reduce myocardial oxygen consumption, anti-angina and effectively stimulate sexual desire. Because of its rapid hydrolysis in the gastrointestinal tract, so this product is oral invalid, drugs used clinically are usually made on a volatile liquid pharmaceutical inhalants, rapidly absorbed in the lungs after inhalation, it can be effective less than half a minute , lasts for only 3 to 10 minutes, the anti-anginal effect nitroglycerin similar, but inhaled dose of this product is difficult to control, and the adverse reaction is large, which is its shortcomings. Because it often causes severe headache, severe hypotension and tachycardia, it is now rarely used in clinical treatment of angina and biliary colic, gradually being replaced by other nitrates. [Adverse reactions and Precautions] Common adverse reactions are headache, facial flushing, hypotension and reflex tachycardia ect. Isoamyl nitrite owns severe reaction than nitroglycerin. Excessive use dosage can cause low blood pressure and heart rate, increase symptoms of angina, heart rate and blood pressure should be closely observed during intravenous drug using. Due to excessive methemoglobin poisoning, symptoms include cyanosis, breathing difficulty and other symptoms of hypoxia, intravenous injection of 1% methylene blue is used for first aid, along with oxygen , and blood transfusions. Usinge for head trauma, brain hemorrhage, acute coronary thrombosis is banned. Using in coronary occlusion and increased intracranial pressure is banned.
Cyanide poisoning antidote	Pharmacological effects are the same with sodium nitrite, isoamyl nitrite is also an oxidizing agent, hemoglobin is oxidized to be high iron (Fe3 +) hemoglobin combines with cyanide ions to form cyanide methemoglobin, eliminates blood free cyanide ions on cytochrome oxidase enzyme infringement, but also makes the cytochrome oxidase bound cyanide ion release, leading to the enzyme activity and tissue respiration function recovery, it should be used simultaneously with sodium thiosulfate to bind with cyanide methemoglobin to form non-toxic thiocyanate group (SCN-) and excreted, and thus play a role in the treatment of cyanide poisoning. This product is administrated by inhalation, rapidly absorbed in the lungs, displays the effects after inhalation of 10 to 30 seconds, the role lasts for 3 to 5 minutes. For emergency use, sodium nitrite is intravenous injected until the symptoms improve. The above information is edited by the Chemicalbook of Tian Ye.
Chemical Properties	Light yellow clear liquid having a boiling point of 99 °C, the relative density is 0.871 (20/4 ℃), the refractive index is 1.3871, the flash point is 10 ℃. It is soluble with alcohol, ether, it can not dissolve in water. With fruit flavor. With volatility, it will break down in the case of light and air .
Uses	It is used in synthesizing perfumes, drugs and diazo compounds. It can be used as an oxidizing agent, solvent. Isobutyl nitrite ester is a drug that is the the fastest short-acting nitrates vasodilator. It is also used as hydrocyanic acid and its salts poisoning antidote.Vasodilators, for the treatment of angina pectoris, also it is used for cyanide poisoning; it is used in synthesizing perfumes, drugs and diazo compounds. It can be used as an oxidizing agent, solvent.
Production method	It is derived from isoamyl alcohol and sodium nitrite. According to the actual production situation, it may have a different method of operation. 1. The reaction takes place in the reaction tube, in synthetic aqueous solution of sodium nitrite, isoamyl alcohol, hydrochloric acid, respectively, are put into the high slot. First sodium nitrite solution and hydrochloric acid solution are dropped at the same rate into the synthesis pipe, when the chlorine gas bubbles in the pipe,isoamyl alcohol is slowly dropped from the top of the pipe, that is in the pipeline synthetic crude. Washed, dried, fractionated to get the products. 2. The reaction is carried out in a reaction tank of sodium nitrite, isoamyl alcohol and water are added to the reaction pot, stirring, cooling to 5 ℃, solution of hydrochloric acid is dropped. At 5 ℃ insulation for 1h, after standing hours to remove the water layer, acetate layer is washed with water, then washed with sodium carbonate solution, and then washed with water. After removing the layer of water, it is dehydrated with anhydrous sodium carbonate, filtered. The filtrate is distilled, collecting 97-99 ℃ distillate, to get isoamyl nitrite.
Category	Flammable liquid
Toxicity grading	Highly toxic
Acute toxicity	Oral-rat LD50: 505 mg/kg; inhalation-mouse LC50: 1430 PPM/30 min
Explosive hazardous characteristics	Heating can be explosive
Flammability hazard characteristics	In the case of fire, high temperature, oxidant, it is flammable; in the case of light, heat may generate toxic nitric oxide gas.
Storage characteristics	Treasury should be ventilation, low-temperature and dry; It should be stored separately from oxidants and acids.
Extinguishing agent	Dry powder, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent.
Chemical Properties	yellow liquid

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