Details:

Avibactam

Avibactam Pharmaceutical Intermediates CAS NO 1192500-31-4 Cas 1192491-61-4

Clinical data
Trade names	Avycaz (formulated with ceftazidime)
License data	EU EMA: by INN
Pregnancy category	US: B (No risk in non-human studies)
Routes of administration	IV
ATC code	None
Legal status
Legal status	US: ?-only
Pharmacokinetic data
Bioavailability	100% (intravenous)
Protein binding	5.7–8.2%[1]
Metabolism	Nil
Onset of action	Increases in proportion to dose
Excretion	Renal (97%)
Identifiers
IUPAC name[hide] [(2S,5R)-2-Carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate
CAS Number	1192500-31-4
PubChem CID	9835049
ChemSpider	8010770
KEGG	D10340
ChEBI	CHEBI:85984 [Yes]
ChEMBL	CHEMBL1689063
Chemical and physical data
Formula	C7H11N3O6S
Molar mass	265.24 g/mol
3D model (JSmol)	Interactive image
SMILES[hide] [C@]12C[N@]([C@@H](CC1)C(N)=O)C(=O)N2OS(O)(=O)=O
InChI[hide] InChI=1S/C7H11N3O6S/c8-6(11)5-2-1-4-3-9(5)7(12)10(4)16-17(13,14)15/h4-5H,1-3H2,(H2,8,11)(H,13,14,15)/t4-,5+/m1/s1 Key:NDCUAPJVLWFHHB-UHNVWZDZSA-N

Avibactam is a non-β-lactam β-lactamase inhibitor[2] developed by Actavis (now [Teva]) jointly with AstraZeneca. A new drug application for avibactam in combination with ceftazidime (branded as Avycaz) was approved by the FDA on February 25, 2015, for treating complicated urinary tract (cUTI) and complicated intra-abdominal infections (cIAI) caused by antibiotic resistant-pathogens, including those caused by multi-drug resistant Gram-negative bacterial pathogens.

Increasing resistance to cephalosporins among Gram-(−) bacterial pathogens, especially among hospital-acquired infections, results in part from the production of β-lactamase enzymes that deactivate these antibiotics. While the co-administration of a β-lactamase inhibitor can restore antibacterial activity to the cephalosporin, previously approved β-lactamase inhibitors such as tazobactam andclavulanic acid do not inhibit important classes of β-lactamases, including Klebsiella pneumoniae carbapenemases (KPCs), New Delhi metallo-β-lactamase 1 (NDM-1), and AmpC-type β-lactamases. Whilst avibactam inhibits class A (KPCs, CTX-M, TEM, SHV), class C (AmpC), and, some, class D serine β-lactamases (such as OXA-23, OXA-48), it has been reported to be a poor substrate/weak inhibitor of class B metallo-β-lactamases, such as VIM-2, VIM-4, SPM-1, BcII, NDM-1, Fez-1.

Advantages:

Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.

1. Quality.Every batch of steroid powders have tobetested by our QC(quality control) before they are allowed to sell.

2 . Delivery We have stock, so we can delivery quickly at the very day when receive the payment. Within 24 hours after receiving the payment Lead time 4 or 7 days.

3 . Discreet package Safelyand Professionally Disguised Package Guaranteed. For your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate

4 . Warm after-sale service Any of your question would be solved for the first as soon as possible.