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99% Phenolphthalein Phenolphthalein Manufacturer For Constipation
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Phenolphthalein Basic information |
Product Name: | Phenolphthalein |
Synonyms: | LABOTEST-BB LT02090809;CI 764;CI NO 764 (1924);BETZ 0212;3,3-BIS(4-HYDROXYPHENYL)-1(3H)-ISOBENZOFURANONE;3,3-Bis(4-hydroxyphenyl)phthalide;3,3-BIS(P-HYDROXYPHENYL)PHTHALIDE;TIMTEC-BB SBB008868 |
CAS: | 77-09-8 |
MF: | C20H14O4 |
MW: | 318.32 |
EINECS: | 201-004-7 |
Product Categories: | Furan&Benzofuran;Analytical Chemistry;Indicator (pH);pH Indicators;Chemistry;Indicator Solutions;Indicators;Titration;Indicator SolutionsStains and Dyes;P;Stains&Dyes, A to;API;Phthalein |
Mol File: | 77-09-8.mol |
Phenolphthalein Chemical Properties |
Melting point | 258-263 °C |
density | 1.299 |
Fp | 24 °C |
solubility | Soluble in alcohol. Slightly soluble in ether. Slightly soluble in dimethyl sulfoxide and insoluble in benzene or hexane. |
form | Solid |
pka | 9.4(at 25℃) |
color | White to yellow-white |
PH Range | 8.0(colorless)-10(Red) |
Water Solubility | <0.1 g/100 mL |
λmax | 552nm, 553nm, 374nm, 205nm, 229nm, 276nm |
Merck | 14,7243 |
BRN | 284423 |
Stability: | Stable. Incompatible with strong oxidizing agents, alkalies. |
Major Application | Display device, sensors, semiconductors, fuel cells, photoreceptors, electronic packaging, authentication system for secure documents, inks, correction fluid, paints, detection of defects in films, floor coatings, textiles, corrosion testing, explosive, concrete, toys, detecting lipase activity of crop seeds, soaps, method for prevention of drugmisuse, cosmetics, diapers, detecting viable cells, carbohydrates, antimalarial, treating amyloid-associated diseases |
CAS DataBase Reference | 77-09-8(CAS DataBase Reference) |
NIST Chemistry Reference | Phenolphthalein(77-09-8) |
EPA Substance Registry System | 1(3H)-Isobenzofuranone, 3,3-bis(4-hydroxyphenyl)-(77-09-8) |
Safety Information |
Hazard Codes | Xn,T,F,Xi |
Risk Statements | 40-22-10-36/38-23/25-11-36/37/38-68-62-45-39/23/24/25-23/24/25 |
Safety Statements | 45-36/37-33-24-16-7-36-26-53 |
RIDADR | UN 1993 |
RTECS | SM8380000 |
TSCA | Yes |
HazardClass | 3 |
PackingGroup | II |
HS Code | 29322910 |
Hazardous Substances Data | 77-09-8(Hazardous Substances Data) |
MSDS Information |
Provider | Language |
---|---|
3,3-Bis(4-hydroxyphenyl)-1(3H)-isobenzofuranone | English |
ACROS | English |
ALFA | English |
Phenolphthalein Usage And Synthesis |
Chemical Properties |
Phenolphthalein is a weak organic acid, at room temperature, appearing as white or microstrip yellow small crystals, being odorless, tasteless, insoluble in water and soluble in alcohol (ethanol) and ether. When dissolved in alcohol solution, it can be made of acid and alkali indicator. It is colorless in acid solution while exhibiting red color in the carbonate solution of alkali metal. However, if placed in the concentrated alkali solution, it will produce colorless tri-metal Salt so that the red color will fade. In view of this feature, laboratory commonly uses it as a kind of acid and alkali titration indicator with the discoloration range of PH being around 8.2 to 10.0, turning from colorless to red. When the phenolphthalein reagent is dropped into water or neutral, acidic aqueous solution, there will be white turbidity. This is due to that the alcohol is easily soluble in water, so that the reagent water-insoluble phenolphthalein is precipitated out. The other major applications are as follows: 1, the pharmaceutical raw materials in pharmaceutical industry: it is suitable for habitual stubborn constipation, including tablets, suppositories and other formulations. 2, it can be used for organic synthesis: mainly used in synthesizing plastics, especially in synthesizing the phthalazinone poly aryl ether ketone poly aryl ether ketone polymers. This kind of polymers, because of its excellent heat resistance, water resistance, corrosion resistance, heat aging resistance and good processability, fibers, coatings and composites made of it are widely used in the fields of electrical and electronic equipment, transportation and aerospace, atomic energy engineering and military. 3, used as acid and alkali indicator, non-aqueous solution titration indicator and chromatography analysis reagents. |
General Description |
Phenolphthalein mainly acts on the large intestine, which produces semi-liquid excreta in 4 to 8 hours with little or no colic. The claim that yellow phenolphthalein is three times stronger than white remains unproven. As a result of enterohepatic circulation, the effect of a single dose is sustainable for 3 to 4 days. The drug is an active member of many laxatives that can be sold legally without prescription. Serious adverse effects are rare but can occur when used in excess. Phenolphthalein should be avoided on the elderly, because its long-term role can cause severe depletion of water and electrolytes. Dermatitis (fixed rash, itching, burning sensation, blistering, and residual pigmentation) can occur in allergic patients. There were reports of a fatal anaphylaxis but no definite causative relationship with phenolphthalein. There are occasional reports of non-thrombocytopenic purpura. Long-lasting administration can occasionally caused dehydration and electrolyte imbalance due to excessive diarrhea. Phenolphthalein causes alkaline urine or faeces pink. |
Application |
This product is a commonly used acid indicator with the range of color change between pH 8.2 (colorless) to 10.0 (red). Phenolphthalein is also a drug, can be used as a laxative, acting on the colon for the treatment of constipation. Used as an acid-base indicator; as irritant laxative for the treatment of constipation |
Production method | It is derived from the condensation of phthalic anhydride and phenol. |
Chemical Properties | white to light yellow crystal powde |
Uses | anthelmintic |
Uses | Used as indicator for acidimetric titrations. |
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