Lidocaine

Details:

 

lidocaine is used in infiltration anesthesia, epidural anesthesia, topical anesthesia (including thoracoscopy or abdominal surgery for mucosal anesthesia) and nerve block. in order to extend the time of anesthesia, reduce the poisoning of lidocaine and other side effects, can be added in the anesthetic epinephrine.

lidocaine can also be used for the treatment of ventricular premature beat after acute myocardial infarction, ventricular tachycardia, digitalis poisoning, cardiac surgery and cardiac catheterization-induced ventricular arrhythmias, including ventricular premature beats, ventricular tachycardia and ventricular fibrillation. lidocaine is also used for duration status of epilepsy which other anti-seizure drugs are not effective, as well as local or spinal anesthesia. but it is usually ineffective for supraventricular arrhythmias.

 

appearance		white or off white crystal powder		complies
solubility		very soluble in methanol and ethanol.		complies
identification
absorbance		nmt0.02 at 420nm(1/20 in methanol)		complies
water		nmt 2.00%		1.02%
residue on ignition		nmt 0.1%		0.05%
heavy metals		nmt 0.001%		complies
total impurities		nmt 0.3%		0.28%
assay		nlt 98.0% and nmt 102.0%		99.0%
(hplc)		calculated on the anhydrous basis
residual solvents by gc
hexanes		nmt 0.029%		0.0058%
ethylacetate		nmt 0.50%		0.1321%
methylenechloride		nmt 0.06%		0.0036%
xylene(mixture)		nmt 0.216%		0.0051%

conclusion:it complies with all the requirements of usp 31.

 

 

 

  

 

topical lidocaine has been shown in some patients to relieve the pain of postherpetic neuralgia (a complication of shingles), though there is not enough study evidence to recommend it as a first-line treatment. iv lidocaine also has uses as a temporary fix for tinnitus. although not completely curing the disorder, it has been shown to reduce the effects by around two thirds. lidocaine hydrochloride injection administered intravenously or intramuscularly, is specifically indicated in the acute management of ventricular arrhythmias such as those occurring in relation to acute myocardial infarction, or during cardiac manipulation, such as cardiac surgery.

 

the efficacy profile of lidocaine as a local anesthetic is characterized by a rapid onset of action and intermediate duration of efficacy. therefore, lidocaine is suitable for infiltration, block, and surface anesthesia. longer-acting substances such as bupivacaine are sometimes given preference for subdural and epidural anesthesias; lidocaine,though, has the advantage of a rapid onset of action.

relative insensitivity to lidocaine is genetic.in hypokalemic sensory overstimulation, relative insensitivity to lidocaine has been described in people who also have attention deficit hyperactivity disorder.in dental anesthesia, a relative insensitivity to lidocaine can occur for anatomical reasons due to unexpected positions of nerves. some people with ehlers-danlos syndrome are insensitive to lidocaine.

lidocaine, along with ethanol, ammonia, and acetic acid, has also been proven to be effective in treating jellyfish stings, both numbing the affected area and preventing further nematocyst discharge.

 

 

 

 

 

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Binbo Biological Co., Ltd. is located in the convenient transportation and beautiful scenery of Jining high-technology industrial zone - Jinxiang economic Development Zone. There is a 105 National road links north and south when Zaocao and Dongfeng Roads connect east and west. Besides, provincial expressway and Ji-Xu expressway which connect Beijing,Shanghai,Fuzhou, and several cities across the JinXiang economic development zone. More importantly, there are only 20 km to Jining airport and close to Qufu high-speed railway station.These convenient geographical conditions bring the development opportunities for this economic development zone.

Binbo Biological Products Co. Ltd., is a professional high-tech enterprise which engaged in Biological products and raw materials. Company was established in 2001, currently our company has more than 28 thousand square meters covering area. Factory buildings and workshops were establishsd by modern production requirements.There are three steps of development project which planned to invest around 60 million RMB. Currently the first step were finished and spent 28 million RMB, which met the production and office requirements.

Binbo is engaged in R&D with perfect equipments and advanced detecting instruments. The factory is in strict accordance with GMP standard in the course of design and construction.

 

 

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