Tocotrienol

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Lenalidomide is a kind of antitumor drugs that developed by American biological pharmaceutical companies. Its chemical structure is similar with thalidomide. It has many functions such as anti-tumor, immune regulation and anti-angiogenesis. It can inhibit the secretion of inflammatory cytokines, and increase the secretion of peripheral blood mononuclear anti-inflammatory cytokines. Vitro tests show that lenalidomide can inhibit the hyperplasia of some cell lines such as namalwa cell. It can inhibit the growth of patients’ multiple myeloma cells and MM1S cell. In addition, lenalidomide also can inhibit the expression of oxidase-2 (COX-2), but it has no effect on COX-1. Two multicenter randomized double-blind placebo-controlled clinical studies evaluate the safety and curative effect of lenalidomide that is used for multiple myeloma. The primary efficacy end point of the studies is time to progression (TTP). The interim analysis shows that TTP of the combination group is significantly superior to dexamethasone group. Recent clinical research results show that lenalidomide not only has curative effect on treating MDS and MM, but also on treating myeloma, leukemia, metastatic renal cell carcinoma, solid tumor, idiopathic generalized amyloidosis and systemic bone marrow fibrosis disease with marrow unripe.
 

 

Lenalidomide is a new derivative of thalidomide. But its teratogenic toxicity has not found. Its effectiveness is 100 times stronger than thalidomide. According to the result of three clinical trials, lenalidomide is the most effective drug in the treatment of multiple myeloma. More than half of patients can prolong survival time to more than 3 years after taking the drug. In addition, it is also the only effective drugs to treat myelodysplastic syndrome (MDS). Clinical results find that 64% of the patients with MDS need not use blood transfusion after treated by lenalidomide. 

 

 

 

 

   

product name	Lenalidomide
assay	99.0% to 101.0%	99.9%
melting point	----	----
loss on drying	0.5%max.	0.22%
sulphated ash	0.1%max.	0.05%
acidity	0.01m naoh<0.50ml	0.39

 

 

 

 

Uses 1. Immunomodulatory drug; analog of Thalidomide.

 

Uses 2. Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM.

 

Uses 3. Lovastatin content <1% 98%

 

Uses 4. A Thalidomide analog known to have immunomodulatory propertie

 

 

 

 

 

1. Air Courier Express Door to Door Service （DHL / TNT / FEDEX / UPS / EMS）

2. Normal Air

3. Normal Sea

 

 

 

 

Binbo Biological Co., Ltd. is located in the convenient transportation and beautiful scenery of Jining high-technology industrial zone - Jinxiang economic Development Zone. There is a 105 National road links north and south when Zaocao and Dongfeng Roads connect east and west. Besides, provincial expressway and Ji-Xu expressway which connect Beijing,Shanghai,Fuzhou, and several cities across the JinXiang economic development zone. More importantly, there are only 20 km to Jining airport and close to Qufu high-speed railway station.These convenient geographical conditions bring the development opportunities for this economic development zone.

Binbo Biological Products Co. Ltd., is a professional high-tech enterprise which engaged in Biological products and raw materials. Company was established in 2001, currently our company has more than 28 thousand square meters covering area. Factory buildings and workshops were establishsd by modern production requirements.There are three steps of development project which planned to invest around 60 million RMB. Currently the first step were finished and spent 28 million RMB, which met the production and office requirements.

Binbo is engaged in R&D with perfect equipments and advanced detecting instruments. The factory is in strict accordance with GMP standard in the course of design and construction.

 

 

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