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10 Gram |
Negotiable |
Dapoxetine hydrochloride Dapoxetine dapoxetine hydrochloride
Dapoxetine, marketed as Priligy and Westoxetin, among and other brands, is the first compound developed specially for the treatment of premature ejaculation (PE) in men 18–64 years old.Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin's action at the post synaptic cleft, and as a consequence promoting ejaculatory delay.As a member of the selective serotonin reuptake inhibitor (SSRI) family, dapoxetine was initially created as an antidepressant. However, unlike other SSRIs, dapoxetine is absorbed and eliminated rapidly in the body. Its fast acting property makes it suitable for the treatment of PE but not as an antidepressant.
Clinical data | |
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Trade names | Priligy, others (see below) |
AHFS/Drugs.com | International Drug Names |
Routes of administration |
Oral (tablets) |
ATC code | |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Bioavailability | 15–76% (mean 42%), Tmax = 1–1.3 hours |
Protein binding | >99% |
Metabolism | Liver (CYP2D6, CYP3A4), kidney (FMO1) |
Metabolites | Dapoxetine-N-oxide, desmethyldapoxetine, didesmethyldapoxetine |
Elimination half-life | 1.5–1.6 h |
Excretion | Kidneys |
Chemical and physical data | |
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Formula | C21H23NO |
Molar mass | 305.413 g/mol |
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