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beclomethasone dipropionate 5534-09-8 beclomethasone dipropionate supplier
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Beclomethasone dipropionate is a potent topical glucocorticoid hormones, have the effect such as anti-inflammatory, anti-allergic and relieving itching, inhibit bronchial exudate, eliminating bronchial mucosal swelling, relieve bronchial spasms.Effect on skin vasoconstriction is far better than hydrocortisone.Topical anti-inflammatory effects is the skin easy to inflammation and loose five times.Lipotropy sex is stronger, easy penetration, apply to affected area shall become effective after 30 minutes.
1.Basic information
CAS Number:5534-09-8
Name:Pregna-1,4-diene-3,20-dione,9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11b,16b)-
Superlist Name:Beclomethasone dipropionate
Formula:C28H37ClO7
Molecular Weight:521.10
Deleted CAS:34135-07-4
Synonyms:9-Chloro-11b,17,21-trihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17,21
dipropionate;Aldecin;
EINECS:226-886-0
Density:1.26 g/cm3
Melting Point:117-120 °C
Boiling Point:630.5 °C at 760 mmHg
Flash Point:335.1 °C
Solubility:slightly soluble in water
Appearance:white crystalline powder
2.COA
Items |
Specifications |
Results |
Appearance |
White to cream white, odorless powder |
White, odorless powder |
Identification (by IR) |
Conforms to the GRS spectrum |
+91.4° |
Loss on drying |
≤0.5% |
0.2% |
Sulphated ash |
≤0.1% |
0.09% |
Assay(by HPLC) |
97.0%~103.0% |
99.7% |
Related substances (by HPLC) |
Any individual impurity ≤1.5% Total impurities≤ 2.0% |
0.28% 0.62% |
Residual solvents |
Ethanol≤5000ppm Methylene chloride ≤600ppm Hexane ≤290ppm Dioxane ≤380ppm Pyridine ≤200ppm |
69ppm 43ppm Undetected (LOD 3ppm) Undetected(LOD 8pppm) Undetected (LOD 4ppm) |
Conclusion: meet the specification according to USP31. |
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