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Betamethasone 378-44-9 Betamethasone supplier
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Product name Betamethasone
CAS No 378-44-9
MF C22H29FO5
MW 400.46
Appearance White to off white powder
Assay 97.0-102.0%
Melting point 236-244℃
specific rotation +115º~+121º
Absorptivity 382-406
Loss on drying NMT 0.5%
Residue on ignition NMT 0.1%
Any other single impurity NMT 0.5%
Total impurities NMT 2.0%
Betamethasone is a corticosteroid used as a topical cream to relieve skin irritation, such as itching and flaking from eczema. It is used as a treatment for local psoriasis, as betamethasone dipropionate andsalicylic acid, or as the combination betamethasone/calcipotriol. Betamethasone sodium phosphate is used orally and via injection with the same indications as other steroids.
A cream with 0.05% betamethasone appears effective in treating phimosis in boys, and often averts the need for circumcision. It has replaced circumcision as the preferred treatment method for some physicians in the British National Health Service.
Betamethasone is also used to stimulate fetal lung maturation (prevention of IRDS), and to decrease the incidence and mortality from intracranial hemorrhage in premature infants.
As it crosses the placenta, which is required for its beneficial effects, it may also be associated with complications, such as hypoglycemia and leukocytosis in newborns exposed in utero.
Test Item |
Details |
Test Result |
Appearance |
white crystal or powder |
white crystal |
Specific rotation |
+63 ~ +70°C |
+64.7°C |
Identification |
infra-red spectrum |
accord with normal frequency spectrum |
Drying Loss |
≤0.5% |
0.4% |
Related Substances |
impurities≤1.5% |
impurities≤0.8% |
>1.0% only one kind of impurity allowed |
>1.0% impurity: none |
|
total impurity≤2.0% |
1.291% |
|
Residue on Ignition |
≤0.2% |
0.03% |
Assay |
≥97.0% |
98.83% |
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