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10 Gram |
Negotiable |
Trilostane Trilostane powder cas 13647-35-3
1.high quality:
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3.low moq:
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Product Name: | Trilostane |
CAS: | 13647-35-3 |
MF: | C20H27NO3 |
MW: | 329.43 |
EINECS: | 237-133-0 |
Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Inhibitor;FULVICIN |
COA
Test Item |
Analysis Specification |
Result |
Description |
White to off-white power |
Conforms |
Purity |
98.5%min |
99.20% |
Water(K.F) |
≤0.5% |
0.20% |
Loss on drying |
≤0.5% |
0.26% |
Residue on ignition |
≤0.1% |
0.04% |
Heavy metals |
≤20ppm |
<20ppm |
Specific optional rotation |
+137°~ +139° |
+138.8° |
Conclusion |
Conform to Company Standard.Packaging & Shipping |
Function
Trilostane is an inhibitor of isoforms 3β-HSD and 3β-HSD2 of the enzyme 3β-hydroxysteroid dehydrogenase, which plays a role in adrenal steroid biosynthesis. Investigators believe that Arg195 in 3∫-HSD versus Pro195 in 3β-HSD2 attributes to the competitive inhibition of 3β-HSD, but not 3β-HSD2 by Trilostane. Research shows that trilostane is effective in suppressing the intracellular production of dihydrotestosterone in LNCaP-FGC prostate cancer cells and inhibiting cortisol biosynthesis in the human adrenal gland. This product serves as a useful tool in steroid biosynthesis research.
Packing and shipping
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