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Zalcitabine 7481-89-2 Zalcitabine supplier
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Name:zalcitabine
Synonyms:2',3'-Dideoxycytidine;Dideoxycytidine;Hivid;NSC 606170;Ro 24-2027/000;ddC
Specification: 99%
CAS NO.: 7481-89-2
Appearance:white to off-white cyrstalline powder
Molecular formula:C9H13N3O3
Molecular weight:211.2178
Melting point:210-214°C
Items |
Specification |
Appearance: |
A white to almost white crystalline powder |
Identification: |
According to USP27 |
Water: |
Not more than 0.3% |
Specific rotation: |
+73 to +77 |
Heavy metals: |
Not more than 20ppm |
Residue on ignition: |
Not more than 0.1% |
Individual impurities: |
Not more than 0.3% |
Total impurities: |
Not more than 2.0% |
pH value(2.5% solution): |
7-8 |
Zalcitabine (2′-3′-dideoxycytidine, ddC), also called dideoxycytidine, is a nucleoside analog reverse transcriptase inhibitor (NRTI) sold under the trade name Hivid. Zalcitabine was the third antiretroviral to be approved by the Food and Drug Administration (FDA) for the treatment of HIV/AIDS. It is used as part of acombination regimen.
Zalcitabine appears less potent than some other nucleoside RTIs, has an inconvenient three-times daily frequency and is associated with serious adverse events. For these reasons it is now rarely used to treat human immunodeficiency virus (HIV), and it has even been removed from pharmacies entirely in some countries.
Zalcitabine is an analog of pyrimidine. It is a derivative of the naturally existing deoxycytidine, made by replacing the hydroxyl group in position 3' with a hydrogen.
It is phosphorylated in T cells and other HIV target cells into its active triphosphate form, ddCTP. This active metabolite works as a substrate for HIV reverse transcriptase, and also by incorporation into the viral DNA, hence terminating the chain elongation due to the missing hydroxyl group. Since zalcitabine is areverse transcriptase inhibitor it possesses activity only againstretroviruses.
Packaging Details:
25kgs packaging Fiber drum outside and plastic bag inside 1-25kgs packaging aluminium bag outside and double plastic bag inside
Delivery Detail: within 3 days when get the payment.
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Product Name: | Polyethylene-polypropylene glycol |
Synonyms: | BLOCK COPOLYMER OF POLYETHYLENE AND POLYPROPYLENE GLYCOL;SYNPERONIC F 108;SYNPERONIC L 121;SYNPERONIC L 122;SYNPERONIC P 105;SYNPERONIC P 85;SYNPERONIC PE(R)/F68;SYNPERONIC PE(R)/L61 |
CAS: | 9003-11-6 |
MF: | C5H10O2 |
MW: | 0 |
EINECS: |
618-355-0 |
Product Name: | Lamivudine |
Synonyms: | LaMivudine(Epivir);4-AMino-1-[(2R,5S)-2-(hydroxyMethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyriMidinone;3TC (-)-1-[(2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine;3TC/Epivir-HBV;4-AMino-1-((2R,5S)-2-(hydroxyMethyl)-1,3-oxathiolan-5-yl)pyriMidin-2(1H)-one;LaMivudine-13C-d2;cis-Lamivudine;(-)-BCH-189 |
CAS: | 134678-17-4 |
MF: | C8H11N3O3S |
MW: | 229.26 |
Product Categories: | API;DENDRID;Piperazines;Active Pharmaceutical Ingredients;Antivirals for Research and Experimental Use;Biochemistry;Chemical Reagents for Pharmacology Research;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents;Anti-virals;Intermediates & Fine Chemicals;Pharmaceuticals;API's;HIV/AIDS/Related Products;Sulfur & Selenium Compounds |
Mol File: |
134678-17-4.mol |
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