142273-20-9 KENPAUL...

142273-20-9 KENPAULLONE C16H11BrN2O
142273-20-9 KENPAULLONE C16H11BrN2O
142273-20-9 KENPAULLONE C16H11BrN2O
142273-20-9 KENPAULLONE C16H11BrN2O
142273-20-9 KENPAULLONE C16H11BrN2O

142273-20-9 KENPAULLONE C16H11BrN2O

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KENPAULLONE 142273-20-9 C16H11BrN2O

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  • Appearance:white powder
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KENPAULLONE Basic information
Product Name: KENPAULLONE
Synonyms: 9-BROMO-7,12-DIHYDRO-INDOLO[3,2-D][1]BENZAZEPIN-6(5H)-ONE;8-BROMO-7,12-DIHYDRO-INDOLO[3,2-D][1]-BENZAZEPIN-6(5H)-ONE;KENPAULLONE;NSC-664704;9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one, NSC 664704;9-bromo-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one;9-BroMopaullone;Kenpaullon
CAS: 142273-20-9
MF: C16H11BrN2O
MW: 327.18
EINECS:
Product Categories: All Inhibitors;Inhibitors;Protein Kinase;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File: 142273-20-9.mol
KENPAULLONE Structure
KENPAULLONE Chemical Properties
Melting point >300°C (dec.)
storage temp. 2-8°C
solubility DMSO: 18 mg/mL, clear, yellow
color yellow
InChIKey QQUXFYAWXPMDOE-UHFFFAOYSA-N
CAS DataBase Reference 142273-20-9(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
KENPAULLONE Usage And Synthesis
Chemical Properties Tan Solid
Uses The paullones are a novel class of kinase inhibitors, initially identified as CDK inhibitors. Kenpaullone has been found to be a useful GSK-3 inhibitor (IC50=23nM).
Biological Activity Potent inhibitor of CDK1/cyclin B and GSK-3 β (IC 50 values are 0.4 and 0.23 μ M respectively). Also inhibits CDK2/cyclin A, CDK2/cyclin E and CDK5/cyclin/p35 (IC 50 values are 0.68, 7.5 and 0.85 μ M respectively). Selective over c-src (IC 50 = 15 μ M), casein kinase 2 (IC 50 = 20 μ M), ERK1 (IC 50 = 20 μ M), ERK2 (IC 50 = 9 μ M) and a range of other protein kinases (IC 50 values > 35 μ M). Generates induced pluripotent stem cells (iPSCs) from somatic cells when used in combination with reprogramming factors; can replace Klf4.
 

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