[4-[[1-[(3-Fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid (3S)-3-morpholinylmethyl ester hydrochloride

Details:

Jinan Trio PharmaTech Co., Ltd. 

 

Year Establishment: 2008

 

Location: We are located at one of the largest National Technical Integrated Drug Discovery Platforms in the High-Tech Zone of Jinan City

 

Our company was founded by a core group of top overseas pharmaceutical chemists, medical scientists business

management experts

 

We have built up solid cooperation with over twenty oversea companies over one hundred domestic companies

since the foundation

 

 

 

 

 

 

 

 

Specifications:

 

 

Name  1,2,4-Triazolo[3,4-f][1,6]naphthyridin-3(2H)-one, 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-

 

 

Molecular Formula  C₂₅H₂₁N₅O

 

 

CAS Registry Number  1032349-93-1  
 

 

Applications:

 

1,2,4-Triazolo[3,4-f][1,6]naphthyridin-3(2H)-one, 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl- (CAS:1032349-93-1) is a

highly selective inhibitor of Akt. Akt1, IC50=8 nM; Akt2, IC50=12 nM; Akt3, IC50=65 nM.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Jinan Trio PharmaTech Co., Ltd. 

 

Year Establishment: 2008

 

Location: We are located at one of the largest National Technical Integrated Drug Discovery Platforms in the High-Tech Zone of Jinan City

 

Our company was founded by a core group of top overseas pharmaceutical chemists, medical scientists business

management experts

 

We have built up solid cooperation with over twenty oversea companies over one hundred domestic companies

since the foundation

 

 

 

 

 

 

 

 

Specifications:

 

 

Name  BMS-599626

 

Synonyms  [4-[[1-[(3-Fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic

acid (3S)-3-morpholinylmethyl ester hydrochloride

 

Molecular Formula  C₂₇H₂₇FN₈O₃.HCl

 

Molecular Weight  567.01

 

CAS Registry Number  873837-23-1
 

 

Applications:

 

BMS-599626 is a highly selective pan-HERKinase inhibitor with IC50 of 20 and 30 nM for the inhibition of HER1and

HER2, respectively.