Compound 7P CAS: 18...

Compound 7P CAS: 1890208-58-8

Compound 7P CAS: 1890208-58-8

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  • Purity: 99%
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Keywords

Compound 1890208-58-8 Compound 7P

Quick Details

  • Appearance: powder or crystal
  • Application:Compound 7P CAS: 1890208-58-8
  • PackAge:Aluminum Foil Bag or as your requirement
  • ProductionCapacity:1000|Metric Ton|Month
  • Storage:keep in dry place
  • Transportation:as your requirement

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Product Name

compound 7p

CAS No.

1890208-58-8

Category

 API

Quality Standard

EP/USP

MSDS

Available

COA

Contact with Effy for updated version COA.

Sample

Available

MOQ

5g

Delivery Date

In 3 days

Place Of Origin

China

Application

Pharmaceutical raw materials

Brand Name

CZG

 

Details:

CAS 1890208-58-8   Compound 7p 

 

CAS :1890208-58-8

 

chemical name:

2-[(2-methoxyphenyl)[4-methylphenyl)sulfonyl]amino]-n-(4-methoxy-3-pyridinyl)acetamide

2-(N-(2-methoxyphenyl)-4-methylphenylsulfonamido)-N-(4-methoxypyridin-3-yl)acetamide

 

molecular formula: c22h23n3o5s

 

linear structure formula: c22h23n3o5s

 

molecular weight: 441.508

 

inchi key : naxwkpfxcobxle-uhfffaoysa-n

 

axon regeneration after injury in the central nervous system is hampered in part because if an age-dependent decline in the intrinsic axon growth potential , and one of the strategies to stimulate axon growth in injured neurons involves pharmacological manipulation of implicated signaling pathways . 

 

here we report phenotypic cell-based screen of chemical libraries and structure-activity-guided optimization that resulted in the identification of compound 7p which promotes neurite outgrowth of cultured primary neurons derived from the hippocampus, cerebral cortex, and retina. in an animal model of optic nerve injury, compound 7p was shown to induce growth of gap-43 positive axons, indicating that the in vitro neurite outgrowth activity of compound 7p translates into stimulation of axon regeneration in vivo. 

 

further optimization of compound 7p and elucidation of the mechanisms by which it elicits axon regeneration in vivo will provide a rational basis for future efforts to enhance treatment strategies.

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Axon regeneration after injury in the central nervous system is hampered in part because if an age-dependent decline in the intrinsic axon growth potential , and one of the strategies to stimulate axon growth in injured neurons involves pharmacological manipulation of implicated signaling pathways.here we report phenotypic cell-based screen of chemical libraries and structure-activity-guided optimization that resulted in the identification of compound 7p which promotes neurite outgrowth of cultured primary neurons derived from the hippocampus, cerebral cortex, and retina. in an animal model of optic nerve injury, compound 7p was shown to induce growth of gap-43 positive axons, indicating that the in vitro neurite outgrowth activity of compound 7p translates into stimulation of axon regeneration in vivo.further optimization of compound 7p and elucidation of the mechanisms by which it elicits axon regeneration in vivo will provide a rational basis for future efforts to enhance treatment strategies.

 
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product advantage
1.our product are of high quality. the purity of hex is above 99.5%.
2.our product have reasonable prices. the more you buy , the lower the price will be.
3.the product will be sent out within 24 hours after getting payment and it will take 4-7 days to arrive your door.
4.our company is a leading professional manufacturer of apis and intermediate product
 
we are  biological technology co.,limited , our company are professional engaged in supplying and exporting many kinds of organic intermedicates products,pharmaceutical intermedicates,research chemicals and raw materials chemicals etc.
i hope you back to me and let me know what chemicals will you need and like , i like to offer you our best price and good quality as your reference .we will choose safe shipping way for you .
Package: 1kg/Aluminum foil bag
Production Capacity: 500 Kilogram/Month
Appearance: white powder
 
Packaging & Shipping

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Packaging Details:

25kgs packaging Fiber drum outside and plastic bag inside 1-25kgs packaging aluminium bag outside and double plastic bag inside

Delivery Detail: within 3 days when get the payment.

 Shipping :
We have Professional shipping agent, based on customers ' demand for transport
By express :FEDEX,DHL,EMS ,UPS,TNT ect.
By SEA and By AIR

 

5.jpg

 

 

Product Name: Polyethylene-polypropylene glycol
Synonyms: BLOCK COPOLYMER OF POLYETHYLENE AND POLYPROPYLENE GLYCOL;SYNPERONIC F 108;SYNPERONIC L 121;SYNPERONIC L 122;SYNPERONIC P 105;SYNPERONIC P 85;SYNPERONIC PE(R)/F68;SYNPERONIC PE(R)/L61
CAS: 9003-11-6
MF: C5H10O2
MW: 0
EINECS: 618-355-0
 

 

 

Product Name: Lamivudine
Synonyms: LaMivudine(Epivir);4-AMino-1-[(2R,5S)-2-(hydroxyMethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyriMidinone;3TC (-)-1-[(2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine;3TC/Epivir-HBV;4-AMino-1-((2R,5S)-2-(hydroxyMethyl)-1,3-oxathiolan-5-yl)pyriMidin-2(1H)-one;LaMivudine-13C-d2;cis-Lamivudine;(-)-BCH-189
CAS: 134678-17-4
MF: C8H11N3O3S
MW: 229.26
Product Categories: API;DENDRID;Piperazines;Active Pharmaceutical Ingredients;Antivirals for Research and Experimental Use;Biochemistry;Chemical Reagents for Pharmacology Research;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents;Anti-virals;Intermediates & Fine Chemicals;Pharmaceuticals;API's;HIV/AIDS/Related Products;Sulfur & Selenium Compounds
Mol File: 134678-17-4.mol
 

 

 

 Product Name  Metroprolol succinate
 Appearance  white powder
 CAS  98418-47-4
 Grade  Medicine & Food
 Other Name  Metroprolol succi 
 Assay  99%min
 Shelf life  2 Years
 Standard  USP30
 Application  Pharmaceutical Raw Intermediates
 Color  white

 

 

 

 

What is Kojic Acid

   Kojic acid is a chelation agent produced by several species of fungi, especially Aspergillus oryzae, which has the Japanese common name koji.Kojic acid is a by-product in the fermentation process of malting rice, for use in the manufacturing of sake, the Japanese rice wine. It is a mild inhibitor of the formation of pigment in plant and animal tissues, and is used in food and cosmetics to preserve or change colors of substances. It forms a bright red complex with ferric ions.

 

 

Applications:

 

♦.Kojic acid can reduces age spots and pigmentation on face and body, typically caused by sun damage. 
♦. It can eliminate free radicals, strengthen cell activity.
♦. Kojic acid is also known to have an anti-microbial effect.
♦. Non-toxic to person and livestock, pollution-free pesticide in insecticide production.

Product Name: Hyaluronic Acid 

 

Product Name: Hyaluronic acid
Synonyms: [BETA-SODIUM-GLUCONATE-(1,3)-BETA-N-ACETYL-D-GLUCOSAMINE-1,4-]N;COPOLY(BETA-GLUCURONIC ACID-[1->3]-BETA-N-ACETYLGLUCOSAMINE-[1->4] SODIUM SALT;HYALURONIC ACID NA-SALT;HYALURONIC ACID, SODIUM SALT, STREPTOCOCCUS SPECIES;HYALURONIC ACID SODIUM;HYALURONIC ACID HUMAN SODIUM SALT;POLY(BETA-GLUCURONIC ACID-[1->3]-BETA-N-ACETYLGLUCOSAMINE-[1->4]), ALTERNATING;SODIUM HYALURONATE (STREPTOCOCCUS)
CAS: 9004-61-9
MF: C14H22NNaO11
MW: 403.31
EINECS:  232-678-0
Mol File: 9004-61-9.mol

 

QQ20160624134407.png

 

 

 

What is Hyaluronic acid 

 

Hyaluronic acid(HA) is a straight chain macromolecular mucopolysaccharide composed Of repeat disaccharide units of glucuronic acid and N-acetylglucosamine. It widely consists in the extracellular space of human and animal tissue, vitreum, umbilical cord, skin joints synovia and cockscomb, etc. The commercial HA is commonly a sodium salt, called sodium hyaluronate, habitually called hyaluronic acid. HA is a new biological at home and abroad. Its molecular weight is from several ten thousand to several million. It's aqueous solution has outstanding moisture keeping ability, high viscoelasticity and lubricity. It is widely used in cosmetics, pharmacy and health and beauty food. 

 

 

Applications:

 

Biochemical drugs with high clinical value, which are widely used in all kinds of eye surgery, such as crystal implantation, corneal transplantation and glaucoma surgery, etc.Can also be used to treat arthritis and accelerate wound healing.Used in cosmetics, it can have unique skin protection effect, can keep skin moist and smooth, delicate, soft, elastic, has the anti-wrinkle, anti-wrinkle, beauty care and restore the skin physiology function.

 

1. Food Grade 
2. Cosmetic Grade 
3. Eyedrops Grade(Pharm Grade) 
4. Injection Grade(Pharm Grade) 
5. High molecular weight HA 
6. Low molecular weight HA

Product Name:Tetrahexyldecyl Ascorbate

 

Product Name:

ASCORBYL TETRA-2-HEXYLDECANOATE

Synonyms:

tetrahexyldecylascorbate;ASCORBYL TETRA-2-HEXYLDECANOATE;L-Ascorbic acid, tetrakis(2-hexyldecanoate);L-Ascorbic acid,2,3,5,6-tetrakis(2-hexyldecanoate);BV-OSC;Nikkol VC-IP;VC-IP;Vitamin C tetra-isopalmitate

CAS:

183476-82-6

MF:

C70H128O10

MW:

1129.76

EINECS:

 

Product Categories:

 

Mol File:

183476-82-6.mol

 

 

Specification example:

 

Item

Specifications

Results

Assay (Icariin) by HPLC

98%

≥99.9%

Appearance

White or light yellow crystalline or crystalline powder

White crystalline powder

character

water-soluble

Conformity with provisions

Odor

odorless

Conformity with provisions

specific rotation

+20.5°~21.5°

+20.1°

Ablaze burning scraps

≤0.1%

0.04%

Heavy metal

≤10mg/kg

<10mg/kg

As

≤3mg/kg

<3mg/kg

Pb

≤2mg/kg

<2mg/kg

Fe

≤2mg/kg

<2mg/kg

Cu

≤5mg/kg

<5mg/kg

Conclusion

The results conforms with GB 14754-2010 standards

 

 

CAS Number:638-94-8
Name:Desonide
Formula:C24H32O6
Molecular Weight:416.51
Synonyms:Prenacid;Desilux;Pregna-1,4-diene-3,20-dione,11,21- dihydroxy-16,17-[(1-methylethylidene)bis- (oxy)]-,(11a,16R)-;Topifug;Locapred;Tridesilon;Flusemidon;Hamiltoderm;Desonide [USAN:BAN:INN];Pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-, (11beta,16alpha)-;Apolar;Otic Tridesilon;Steroderm;Prednisolone-16,17-acetonide, 16-alpha-hydroxy-;DesOwen;Tridesonit;Sterax;Desonidum [INN-Latin];Budesonide acetonide;
EINECS:211-351-6
Density:1.3 g/cm3
Boiling Point:580.1 °C at 760 mmHg
Flash Point:196.9 °C
Appearance:Powder

Application:

1. Can be absorbed through the skin antikeratinizing, stimulate the growth of collagen and elastin, increase the thickness of the epidermis and dermis. Enhance skin elasticity, eliminate wrinkles and promote skin renewal, keeping the skin vitality. For cream, moisturizing cream, Cream, shampoo, conditioner, etc.
2. Vitamin A acetate oil to maintain the body's normal metabolism, cell membrane to maintain stability and development, to maintain the normal function of the reproductive system, formation of the visual, ease keratinized tissue, enhance immunity cells have significant effects.

 

    Product Description

                                               
Cabazitaxel CAS 183133-96-2 Brand:sigma
MW: 835.93 MSDS: Avaiable
MF :C45H57NO14 Sample: Avaiable
Category: Oncology drug Min order: 1grams
Quality standard Enterprise standard  Place of Origin:China
Appearance White   powder
Introduction is a semi-synthetic derivative of a natural taxoid.It was developed by Sanofi-Aventis and was approved by the U.S. Food and Drug Administration (FDA) for the treatment of hormone-refractory prostate cancer on June 17, 2010. It is a microtubule inhibitor, and the fourth taxane to be approved as a cancer therapy.
Applications Pharmaceutical raw materials , Oncology drug

 

   Certification of Analysis

 

 

TEST ITEM

SPECIFICATION

Appearance

White or almost white crystalline powder

Identification

FT-IR

HPLC

Water

3.0%

Melting Point

148°C­—158°C 

Residue on Ignition

≤0.1%

Heavy metals

≤ 20ppm

 

 

 

 Residual  Solvents

Acetone

≤ 5000ppm

Dichloromethane

≤ 600ppm

n-Hexane

≤ 290ppm

Acetic acid

≤ 5000ppm

Ethyl acetate

≤ 5000ppm

Tetrahydrofuran

≤ 720ppm

Ethanol

≤ 5000ppm

Related

substances

cabazitaxel

≤ 0.3%

10-DABIII

≤ 0.3%

Any other single impurity

≤ 0.1%

Total impurities

≤ 1.0%

Chromatographic purity(By HPLC)

≥99.0%

 

                          Function&Application

 

 

Cabazitaxel (previously XRP-6258) is a semi-synthetic derivative of a natural taxoid. It was developed by Sanofi-Aventis and was approved by the U.S. FDA for the treatment of hormone-refractory prostate cancer on June 17, 2010. It is a microtubule inhibitor, and the fourth taxane to be approved as a cancer therapy.

Cabazitaxel in combination with prednisone is a treatment option for hormone-refractory prostate cancer following docetaxel-based treatment.

 

 Cabazitaxel anticancer mechanism and characteristics similar with docetaxel, belongs to anti-microtubule drugs. Cabazitaxel through binding to tubulin, promoting their assembly into microtubules, and can prevent these have assembled a microtubule disintegration of the stabilization of microtubules, thereby inhibiting cell mitosis, and interphase cellular functions (interphasecellularfunctions) of play.

    Product Description

Cephalomannine was first discovered in the tree, Cephalotaxus mannii. Since then, it has been discovered in yew trees, Taxus sp., and is commonly eluted with taxol during extract purification.
 
Product Name
Cephalomannine
Used Part
Bark
Specification
93%~99%
Appearance
White powder
CAS NO.
71610-00-9
Test Method
HPLC
Extraction type
Solvent Extraction
Molecular Formula
C45H53NO14
Molecular Weight
831.91
Shelf life
2 years  
Place ofOrigin
Shandong,China(Mainland)

   Certification of Analysis

 

 

Product Information
Product Name Docetaxel Anhydrous 
Molecular Formula C43H53NO14 (807.88)
Cas No. 114977-28-5
Quality standard complies with In-house Standard
Analysis Standard
Assay(W/W) 93.0-102.0%
Purity(HPLC) ≥93.8%
Physical Control
Appearance White crystalline powder
Identification Conforms
Specific Optical Rotation -40°~-47°
Water ≤3.0%
Chemical Control
Residue of solvents Complies with ICH requirement
Residue on Ignition NMT0.2%
Bacteria Endotoxins 0.4EU/MG
Heavy Metal NMT20ppm
Chromatographic Impurities 
Highest Individual Impurity NMT0.1%
Unknown Impurity NMT0.1%
Total Impurity NMT0.5%
Microbiological Control 
Total Aerobic Microbial Count NMT 100cfu/g
S.Aureus & Aeruginosa Negative
Salmonella & E.Coil Negative
Storage
Store at 2-8°C, In well closed containers and protect from light and moisture

 

                          Function&Application

 

 

Function:

Pharmacological Function:

It is a kind of anticancer drugs. It has the curative effect on many kinds of cancers, extremely

on the ovarian cancer, breast cancer. Its cure rate reaches to 33%, effectiveness to 75%.

 

Application:

1.Medical Purpose:

a. Used to treat patients with lung, ovarian, breast advanced forms of Kaposi's sarcoma.

b. Used for the prevention of restenosis. 

2.Food Additive

3.Cosmetics

4.Forage Additive

Product description

Product Name:  100% Natural Stevia Extract Powder --natural stevia rebaudiana extract/57817-89-7  

Latin Name: Stevia rebaudiana (Bertoni) Hemsl

Appearance:  White crystalline powder

Part Used:  Dried whole plant

Active Ingredient:  Steviosides RA/Rebaudioside A

Specification: Steviosides: 80%- 95% 

CAS No :  57817-89-7

Molecular formula: C38H60O18
Molecular Weight: 804.88

Test method: HPLC

Supplier: Hunan World well-being Bio-tech.

Functions

 

Items  specification                                                    results                                    
appearance             fluffy white powder standard 
 viscosity (20 r/min,25 ℃ ,mpa,s)                 19000-35000 21000
solution clarity (420 nm,%) 40000-60000 55700
heavy metals (mg/kg) AS <2 pass
heavy metals (mg/kg) Pb+As+Hg+Sb <10 pass
packing density (g/100ml) 21.0-27.0 pass
loss and drying(%) <2.0  pass
Residual Acrylic acid(%) <0.25 0.16
Residual Benzene (%) <0.50 0.4

 

Items

Specification

Appearance

White or almost white powder or   crystalline powder, odorless

Melting point

152~156℃

Specific rotation

-16.0°~ -19.0°

Identification

1) The retention time of the major peak in the chromatogram of the assay preparation corresponds to that in the chromatogram of the standard preparation, as obtained in assay.

 

2) IR spectra is consistent with CRS.

pH

4.5~6.5

Chlorides

0.02%

Fluorides

4.8%

Related substances

Individual impurity    0.5%

      Total impurity        2.0%

Loss on drying

0.5%

Residue on ignition

0.1%

Heavy metals

20ppm

Assay

98.0%

 

product Name Hydroxyurea
Synonyms Hydroxycarbamide; 1-hydroxyurea; Biosupressin; sq 1089; wr 83799; Carbamohydroxamic acid; Carbamohydroximic acid; Carbamoyl oxime; Carbamyl hydroxamate; Hidrix; Hidroxicarbamida; HU; Hydrea; Hydreia; Hydroxycarbamine; Hydroxylurea; hydroxy urea (d4); Hydura; Hydurea; Litaler; Litalir; N-(aminocarbonyl)hydroxylamine; N-Carbamoylhydroxylamine; N-Hydroxyurea; Onco-carbide; Oxyurea; sk 22591; Hydroxy urea; amino(oxido-λ5-azanyl)methanone
Molecular Formula CH4N2O2
Molecular Weight 76.0547
InChI InChI=1/CH4N2O2/c2-1(4)3-5/h3H2,(H2,2,4)
CAS Registry Number 127-07-1
EINECS 204-821-7
Water solubility soluble
Density 1.733g/cm3
Melting point 142-146°C
Refractive index 1.543
   

 

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