Compound 7P CAS: 1890208-58-8

Details:

CAS 1890208-58-8   Compound 7p 

 

CAS :1890208-58-8

 

chemical name:

2-[(2-methoxyphenyl)[4-methylphenyl)sulfonyl]amino]-n-(4-methoxy-3-pyridinyl)acetamide

2-(N-(2-methoxyphenyl)-4-methylphenylsulfonamido)-N-(4-methoxypyridin-3-yl)acetamide

 

molecular formula: c22h23n3o5s

 

linear structure formula: c22h23n3o5s

 

molecular weight: 441.508

 

inchi key : naxwkpfxcobxle-uhfffaoysa-n

 

axon regeneration after injury in the central nervous system is hampered in part because if an age-dependent decline in the intrinsic axon growth potential , and one of the strategies to stimulate axon growth in injured neurons involves pharmacological manipulation of implicated signaling pathways . 

 

here we report phenotypic cell-based screen of chemical libraries and structure-activity-guided optimization that resulted in the identification of compound 7p which promotes neurite outgrowth of cultured primary neurons derived from the hippocampus, cerebral cortex, and retina. in an animal model of optic nerve injury, compound 7p was shown to induce growth of gap-43 positive axons, indicating that the in vitro neurite outgrowth activity of compound 7p translates into stimulation of axon regeneration in vivo. 

 

further optimization of compound 7p and elucidation of the mechanisms by which it elicits axon regeneration in vivo will provide a rational basis for future efforts to enhance treatment strategies.

Axon regeneration after injury in the central nervous system is hampered in part because if an age-dependent decline in the intrinsic axon growth potential , and one of the strategies to stimulate axon growth in injured neurons involves pharmacological manipulation of implicated signaling pathways.here we report phenotypic cell-based screen of chemical libraries and structure-activity-guided optimization that resulted in the identification of compound 7p which promotes neurite outgrowth of cultured primary neurons derived from the hippocampus, cerebral cortex, and retina. in an animal model of optic nerve injury, compound 7p was shown to induce growth of gap-43 positive axons, indicating that the in vitro neurite outgrowth activity of compound 7p translates into stimulation of axon regeneration in vivo.further optimization of compound 7p and elucidation of the mechanisms by which it elicits axon regeneration in vivo will provide a rational basis for future efforts to enhance treatment strategies.

 

 

 

 

 

 

 

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Package: 1kg/Aluminum foil bag

Production Capacity: 500 Kilogram/Month

Appearance: white powder

 

Packaging & Shipping

Packaging Details:

25kgs packaging Fiber drum outside and plastic bag inside 1-25kgs packaging aluminium bag outside and double plastic bag inside

Delivery Detail: within 3 days when get the payment.

 Shipping :
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What is Kojic Acid

   Kojic acid is a chelation agent produced by several species of fungi, especially Aspergillus oryzae, which has the Japanese common name koji.Kojic acid is a by-product in the fermentation process of malting rice, for use in the manufacturing of sake, the Japanese rice wine. It is a mild inhibitor of the formation of pigment in plant and animal tissues, and is used in food and cosmetics to preserve or change colors of substances. It forms a bright red complex with ferric ions.

Applications:

♦.Kojic acid can reduces age spots and pigmentation on face and body, typically caused by sun damage. 
♦. It can eliminate free radicals, strengthen cell activity.
♦. Kojic acid is also known to have an anti-microbial effect.
♦. Non-toxic to person and livestock, pollution-free pesticide in insecticide production.

Product Name: Hyaluronic Acid 

What is Hyaluronic acid 

Hyaluronic acid(HA) is a straight chain macromolecular mucopolysaccharide composed Of repeat disaccharide units of glucuronic acid and N-acetylglucosamine. It widely consists in the extracellular space of human and animal tissue, vitreum, umbilical cord, skin joints synovia and cockscomb, etc. The commercial HA is commonly a sodium salt, called sodium hyaluronate, habitually called hyaluronic acid. HA is a new biological at home and abroad. Its molecular weight is from several ten thousand to several million. It's aqueous solution has outstanding moisture keeping ability, high viscoelasticity and lubricity. It is widely used in cosmetics, pharmacy and health and beauty food. 

Applications:

Biochemical drugs with high clinical value, which are widely used in all kinds of eye surgery, such as crystal implantation, corneal transplantation and glaucoma surgery, etc.Can also be used to treat arthritis and accelerate wound healing.Used in cosmetics, it can have unique skin protection effect, can keep skin moist and smooth, delicate, soft, elastic, has the anti-wrinkle, anti-wrinkle, beauty care and restore the skin physiology function.

1. Food Grade 
2. Cosmetic Grade 
3. Eyedrops Grade(Pharm Grade) 
4. Injection Grade(Pharm Grade) 
5. High molecular weight HA 
6. Low molecular weight HA

Product Name:Tetrahexyldecyl Ascorbate

Specification example:

CAS Number:638-94-8
Name:Desonide
Formula:C24H32O6
Molecular Weight:416.51
Synonyms:Prenacid;Desilux;Pregna-1,4-diene-3,20-dione,11,21- dihydroxy-16,17-[(1-methylethylidene)bis- (oxy)]-,(11a,16R)-;Topifug;Locapred;Tridesilon;Flusemidon;Hamiltoderm;Desonide [USAN:BAN:INN];Pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-, (11beta,16alpha)-;Apolar;Otic Tridesilon;Steroderm;Prednisolone-16,17-acetonide, 16-alpha-hydroxy-;DesOwen;Tridesonit;Sterax;Desonidum [INN-Latin];Budesonide acetonide;
EINECS:211-351-6
Density:1.3 g/cm3
Boiling Point:580.1 °C at 760 mmHg
Flash Point:196.9 °C
Appearance:Powder

Application:

1. Can be absorbed through the skin antikeratinizing, stimulate the growth of collagen and elastin, increase the thickness of the epidermis and dermis. Enhance skin elasticity, eliminate wrinkles and promote skin renewal, keeping the skin vitality. For cream, moisturizing cream, Cream, shampoo, conditioner, etc.
2. Vitamin A acetate oil to maintain the body's normal metabolism, cell membrane to maintain stability and development, to maintain the normal function of the reproductive system, formation of the visual, ease keratinized tissue, enhance immunity cells have significant effects.

    Product Description

   Certification of Analysis

                          Function&Application

Cabazitaxel (previously XRP-6258) is a semi-synthetic derivative of a natural taxoid. It was developed by Sanofi-Aventis and was approved by the U.S. FDA for the treatment of hormone-refractory prostate cancer on June 17, 2010. It is a microtubule inhibitor, and the fourth taxane to be approved as a cancer therapy.

Cabazitaxel in combination with prednisone is a treatment option for hormone-refractory prostate cancer following docetaxel-based treatment.

 Cabazitaxel anticancer mechanism and characteristics similar with docetaxel, belongs to anti-microtubule drugs. Cabazitaxel through binding to tubulin, promoting their assembly into microtubules, and can prevent these have assembled a microtubule disintegration of the stabilization of microtubules, thereby inhibiting cell mitosis, and interphase cellular functions (interphasecellularfunctions) of play.

    Product Description

   Certification of Analysis

                          Function&Application

Function:

Pharmacological Function:

It is a kind of anticancer drugs. It has the curative effect on many kinds of cancers, extremely

on the ovarian cancer, breast cancer. Its cure rate reaches to 33%, effectiveness to 75%.

Application:

1.Medical Purpose:

a. Used to treat patients with lung, ovarian, breast advanced forms of Kaposi's sarcoma.

b. Used for the prevention of restenosis. 

2.Food Additive

3.Cosmetics

4.Forage Additive