Imatinib mesylate Imatinib methanesulfonate salt mesylate
<p> <span style="font-family: Verdana, Arial, Helvetica, sans-serif; color: rgb(51,51,51)">Imatinib mesylate is a small molecule that inhibits the c-Abl protein-tyrosine kinase, a kinase specifically important fproliferation ofonic myelogenous leukemia (CML). A translocation event betweenomosomes 9 22 generates the Philadelphiaomosome, which then produces the Bcr-Abl fusion protein with aberrant kinase activity that promotes rapid cell proliferation. Imatinib binds up this crucial kinase, halting CML related growth. Imatinib mesylate has further been displayed to inhibit PDGFR tyrosine kinases associated with c-Kit.</span></p> <p> </p> <div class="Section0"> <p class="p0" style="margin-top: 0pt; margin-bottom: 0pt"> <span style="font-family: '宋体'; font-size: 10.5pt; mso-spacerun: 'yes'"><o:p></o:p></span></p> </div> <p> </p>
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