53910-25-1 PENTOST...

53910-25-1 PENTOSTATIN C11H16N4O4

53910-25-1 PENTOSTATIN C11H16N4O4

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PENTOSTATIN 53910-25-1 C11H16N4O4

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  • Appearance:Powder
  • Application:53910-25-1
  • PackAge:Aluminium Foil Bag and Paper Drum
  • ProductionCapacity:1|Metric Ton|Day
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Details:

 
PENTOSTATIN Basic information
Product Name: PENTOSTATIN
Synonyms: CL-67310465：NSC-218321;(8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8β-ol;(8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol;Coforin;2'-DeoxycoforMycin, Covidaribine, ADAI, CI 825, d-Cof, NSC 218321, PD-ADI, YK 176;Pentostatin(Deoxycoformycin);Pentostatin, >=99%;(R)-3-((2S,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
CAS: 53910-25-1
MF: C11H16N4O4
MW: 268.27
EINECS:  
Product Categories: Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Protein Kinase Inhibitors and Activators;NULL
Mol File: 53910-25-1.mol
PENTOSTATIN Structure
 
PENTOSTATIN Chemical Properties
Melting point  154-157 C
alpha  D25 +76.4° (c = 1 in water); D23 +73.0° (c = 1, pH 7 buffer)
Boiling point  411.43°C (rough estimate)
density  1.2576 (rough estimate)
refractive index  1.6081 (estimate)
storage temp.  Store at +4°C
solubility  H2O: soluble10mg/mL, clear
pka 5.2(at 25℃)
color  white to beige
 
Safety Information
Hazard Codes  Xn
Risk Statements  22
RIDADR  UN 2811 6.1 / PGIII
MSDS Information
 
 
PENTOSTATIN Usage And Synthesis
Chemical Properties White Solid
Uses Pentostatin is a potent antitumour antibiotic isolated from a Streptomyces species. Pentostatin is a potent inhibitor of adenine deaminase and has been used therapeutically as an antitumour agent.
Uses Pentostatin is a potent antitumor antibiotic isolated from a Streptomyces species. Pentostatin is a potent inhibitor of adenine deaminase and has been used therapeutically as an antitumor agent.
Uses An adenosine deaminase inhibitor used as an anti-cancer therapeutic drug. Shown to be effective in the treatment of hairy cell leukemia as well as having use in the treatment of other types of cancer such as chronic lymphocytic leukemia.
Biological Activity Irreversible inhibitor of adenosine deaminase (K i = 2.5 pM). Anticancer agent.

 

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