AZASERINE 115-02-6 C5H7N3O4
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AZASERINE Basic information |
Product Name: | AZASERINE |
Synonyms: | serine,diazoacetate(ester);AZASERINE;AZASERINE CRYSTALLINE;AZASERINE (50X) GAMMA-IRRADIATED CELLCUL TURE TESTE;ORTHO-DIAZOACETYL-L-SERINE;DIAZOACETYLSERINE;2-aMino-3-(2-diazoacetoxy)propanoic acid;O-DIAZOACETYL-L-SERINE |
CAS: | 115-02-6 |
MF: | C5H7N3O4 |
MW: | 173.13 |
EINECS: | 204-061-6 |
Product Categories: | Antibiotics |
Mol File: | 115-02-6.mol |
AZASERINE Chemical Properties |
Melting point | 146-162° (dec) |
alpha | D27.5 -0.5° (c = 8.46% in H2O at pH 5.18) |
Boiling point | 303.75°C (rough estimate) |
density | 1.5830 (rough estimate) |
refractive index | 1.6190 (estimate) |
storage temp. | 2-8°C |
solubility | H2O: 50 mg/mL, clear, yellow |
pka | 8.55(at 25℃) |
form | lyophilized powder |
Merck | 13,902 |
Safety Information |
Hazard Codes | T |
Risk Statements | 25-40 |
Safety Statements | 53-36/37/39-45 |
RIDADR | UN 3462 6.1/PG 3 |
WGK Germany | 3 |
RTECS | VT9625000 |
F | 10 |
HazardClass | 6.1(b) |
PackingGroup | III |
Toxicity | LD50 in mice, rats (mg/kg/day): 150, 170 orally (Sternberg, Philips) |
MSDS Information |
Provider | Language |
---|---|
SigmaAldrich | English |
AZASERINE Usage And Synthesis |
Uses | antineoplastic, amino acid antagonist |
Definition | ChEBI: A carboxylic ester resulting from the formal condensation of the carboxy group of diazoacetic acid with the alcoholic hydroxy group of L-serine. An antibiotic produced by a Streptomyces species. |
Uses | Reagent used to induce pancreatic cancer in experimental animal models. |
General Description | Pale yellow to green crystals. Used as an antifungal agent. |
Air & Water Reactions | Very soluble in water. |
Reactivity Profile | AZASERINE is incompatible with acids. |
Purification Methods | Crystallise azaserine from 90% EtOH. Also dissolve it in H2O, filter it through Supercel and add EtOH to give azaserine as pale yellow crystals. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 1 pp 75-76 1961, Curphey & David J Org Chem 43 4666 1978, Beilstein 4 IV 3124.] |
AZASERINE Preparation Products And Raw materials |
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