28643-80-3 C40H67O...

28643-80-3 C40H67O11Na Nigericin sodium salt

28643-80-3 C40H67O11Na Nigericin sodium salt

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Nigericin sodium salt 28643-80-3 C40H67O11Na

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  • Appearance:Powder
  • Application:28643-80-3
  • PackAge:Aluminium Foil Bag and Paper Drum
  • ProductionCapacity:1|Metric Ton|Day
  • Storage:1MT
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Details:

Nigericin sodium salt Basic information
Product Name: Nigericin sodium salt
Synonyms: Polyetherin A, Azalomycin M, Helixin C, Antibiotic K178, Antibiotic X-464;Antibiotic K178, Antibiotic X464, Azalomycin M, Helexin C, Polyetherin A;Sodium (2R)-2-[(3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)-2-[(5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl]-3-methyloxan-2-yl]propanoate;Nigericin sodium salt;Nigericin, monosodium salt;Nsc292567;Nigericin sodium salt,Antibiotic K178, Antibiotic X464, Azalomycin M, Helexin C, Polyetherin A;Nigericin sodiuM sa
CAS: 28643-80-3
MF: C40H67O11Na
MW: 746.94
EINECS:  
Product Categories: API
Mol File: 28643-80-3.mol
Nigericin sodium salt Structure
 
Nigericin sodium salt Chemical Properties
storage temp.  2-8°C
solubility  Soluble in chloroform, methanol or ethanol
Merck  13,6569
InChIKey MOYOTUKECQMGHE-NTQCAYBPSA-M
 
Safety Information
Hazard Codes  T
Risk Statements  25-36/37/38
Safety Statements  26-36/37/39-45
RIDADR  UN 3462 6.1/PG 3
RTECS  QT6840000
HazardClass  6.1
HS Code  29419090
MSDS Information
 
 
Nigericin sodium salt Usage And Synthesis
Chemical Properties White powder
Uses Nigericin sodium is the atypical salt of nigericin. Since nigericin is an ionophore, its very high affinity for monovalent cations such as Na+ and K+ means that formation of a salt is a facile possess occurring during purification under any but highly acidic conditions. Typically, the salts of polyether ionophores like the free acid, are readily extracted into organic solvents. The sodium ion is stabilised within a polar pocket of the structure, effectively making the salt and free acid different chemical moieties with the potential for differing pharmacology, a fact not readily appreciated in the literature.
Uses Nigericin sodium is a salt of the atypical polyether antibiotic, nigericin. Since nigericin is an ionophore, its very high affinity for monovalent cations such as Na+ and K+ means that formation of a salt is a facile possess occurring during purification under any but highly acidic conditions. Typically, the salts of polyether ionophores like the free acid, are readily extracted into organic solvents. The sodium ion is stabilised within a polar pocket of the structure, effectively making the salt and free acid different chemical moieties with the potential for differing pharmacology, a fact not readily appreciated in the literature.
 
Nigericin sodium salt Preparation Products And Raw materials

 

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