307510-92-5 C18H10F...

307510-92-5 C18H10F3NO3S2 CFTRinh-172
307510-92-5 C18H10F3NO3S2 CFTRinh-172
307510-92-5 C18H10F3NO3S2 CFTRinh-172
307510-92-5 C18H10F3NO3S2 CFTRinh-172
307510-92-5 C18H10F3NO3S2 CFTRinh-172

307510-92-5 C18H10F3NO3S2 CFTRinh-172

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Keywords

CFTRinh-172 307510-92-5 C18H10F3NO3S2

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  • Appearance:white powder
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CFTRinh-172 Basic information
Product Name: CFTRinh-172
Synonyms: 3-[(3-Trifluoromethyl)Phenyl]-5-[(4-Carboxyphenyl)Methylene]-2-Thioxo-4-Thiazolidinone 4-[(Z)-[4-Oxo-2-Sulfanylidene-3-[3-(Trifluoromethyl)Phenyl]-1,3-Thiazolidin-5-Ylidene]Methyl]Benzoic Acid;4-[[4-Oxo-2-Thioxo-3-[3-(Trifluoromethyl)Phenyl]Thiazolidin-;InSolution CFTR Inhibitor-172;CFTR(INH)-172;CFTR INHIBITOR-172;5-[(4-CARBOXYPHENYL)METHYLENE]-2-THIOXO-3-[(3-TRIFLUOROMETHYL)PHENYL-4-THIAZOLIDINONE];3-[(3-TRIFLUOROMETHYL)PHENYL]-5-[(4-CARBOXYPHENYL)METHYLENE]-2-THIOXO-4-THIAZOLIDINONE;4-[4-OXO-2-THIOXO-3-(3TRIFLUOROMETHYL-PHENYL)-THIAZOLIDIN-5-YLIDENEMETHYL]-BENZOIC ACID (FOR R&D ONLY)
CAS: 307510-92-5
MF: C18H10F3NO3S2
MW: 409.4
EINECS:
Product Categories: Inhibitors
Mol File: 307510-92-5.mol
CFTRinh-172 Structure
CFTRinh-172 Chemical Properties
storage temp. Store at +4°C
solubility DMSO: ≥10mg/mL
color yellow
Safety Information
Hazard Codes Xi,N
Risk Statements 36/37/38-43-50/53
Safety Statements 26-36/37-60-61
RIDADR UN 3077 9 / PGIII
HazardClass IRRITANT
MSDS Information
CFTRinh-172 Usage And Synthesis
Definition ChEBI: A thiazolidinone that is 2-thioxo-4-thiazolidinone which is substituted at position 3 by a (m--trifluoromethyl)phenyl group and at position 5 by a p-carboxybenzylidene group. It is an inhibitor of cystic fibrosis transmembrane con uctance regulator, a membrane protein and chloride channel in vertebrates that is encoded by the CFTR gene.
Uses The cystic fibrosis (CF) gene encodes a cAMP-regulated chloride channel, the CF transmembrane conductance regulator (CFTR). CFTR Inhibitor-172 is a thiazolidinone that selectively blocks the CFTR channel (Ki = 300 nM) in a voltage-independent manner. It appears to directly modulate the gating of chloride at the channel and does not prevent elevation of cAMP or inhibit other pumps or channels. In mice, CFTR inhibitor-172 prevents cholera toxin-induced fluid secretion in the small intestine, when given by intraperitoneal injection. It slows cyst growth in animal models of polycystic kidney disease. As CFTR also modulates glutathione (GSH) efflux, CFTR inhibitor-172 can affect intracellular GSH concentration and reactive oxygen species balance.
Biological Activity Voltage-independent, selective CFTR chloride channel blocker (K i = 300 nM) that alters channel gating. Blocks intestinal fluid secretion induced by cholera toxin and Escherichia coli and suppresses cyst growth in animal models of polycystic kidney disease. Orally active. Inhibits mitochondrial respiration and increases reactive oxygen species (ROS) production independently of CFTR in several cell lines.
 
 
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