4-Aminobutyric acid...

4-Aminobutyric acid,gamma-aminobutyric acid(GABA)

4-Aminobutyric acid,gamma-aminobutyric acid(GABA)

Min.Order / FOB Price:Get Latest Price

50 Gram

Negotiable

  • Min.Order :50 Gram
  • Purity: ≥ 99.5%
  • Payment Terms : L/C,T/T

Keywords

natural plant extract bio-tech γ-aminobutyric acid (GABA)

Quick Details

  • Appearance:white or off-white crystalline powder
  • Application:Used in food additive, feed additive,pharm,cosmetic and so on
  • PackAge:25kg drum or upto customers'requirement
  • ProductionCapacity:2|Metric Ton|Day
  • Storage:Stored in cool and draughty place and do not store it together with alkaline chemicals.
  • Transportation:by sea or by air

Superiority:

Sincerity Enterprise Ltd has much experience focused on providing integrated development and manufacturing service to Pharmaceutical,Additives,Fine Chemicals, Electronic chemicals and so on.
 
Our company located at Hangzhou City of China, the transportation is very convenient, it is near Shanghai Or Ningbo Port. We owned independent research and development center, with many domestic famous universities cooperation and common development project, and owned experimental platform to meet various process technology.
 
Sincerity Enterprise Ltd uphold "the most reliable partner for customer"as business concept and "with the high quality product, excellent service to win customers’trust, constantly and effectively improve the quality management system to meet customers’ requirements”as the quality policy, and constantly develops advanced technology and produces high performance chemicals. 
 
Warmly welcome our new and old customers to come to talks and investigation, Sincerely look forward to cooperating together and create a better future.

Details:

Chemical Name:GABA(gamma aminobutyric acid),4-aminobutyric acid, gammalon, piperidic acid 

                                Structure: NH2CH2CH2CH2COOH 

Molecular formula: C4H9NO2   Molecular Weight: 103.12

 Gamma Aminobutyric Acid (GABA)is the chief inhibitory neurotransmitter in the mammalian central nervous system. It plays a role in regulating neuronal excitability throughout the nervous system. In humans, GABA is also directly responsible for the regulation of muscle tone.Although chemically it is an amino acid, GABA is rarely referred to as such in the scientific or medical communities, because the term "amino acid," used without a qualifier, conventionally refers to the alpha amino acids, which GABA is not, nor is it ever incorporated into a protein.In spastic diplegia in humans, GABA absorption becomes impaired by nerves damaged from the condition's upper motor neuron lesion, which leads tohypertonia of the muscles signaled by those nerves that can no longer absorb GABA.

When you are using this chemical, please be cautious about it as the following:
It is not only harmful by inhalation, in contact with skin and if swallowed, but also irritating to eyes, respiratory system and skin. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing.

People can use the following data to convert to the molecule structure.
1. SMILES:C(CC(=O)O)CN
2. InChI:InChI=1/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7) 
3. InChIKey:BTCSSZJGUNDROE-UHFFFAOYAC

The following are the toxicity data which has been tested.
 

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intravenous 5gm/kg (5000mg/kg)   Russian Pharmacology and Toxicology Vol. 47, Pg. 205, 1984.
mouse LD50 intraperitoneal 4950mg/kg (4950mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Archivum Immunologiae et Therapiae Experimentalis. Vol. 13, Pg. 70, 1965.
 
mouse LD50 intravenous 2748mg/kg (2748mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 145, Pg. 233, 1963.
mouse LD50 oral 12680mg/kg (12680mg/kg)   Yakugaku Zasshi. Journal of Pharmacy. Vol. 85, Pg. 463, 1965.
mouse LD50 subcutaneous 9210mg/kg (9210mg/kg)   Yakugaku Zasshi. Journal of Pharmacy. Vol. 85, Pg. 463, 1965.
mouse LD50 unreported 7230mg/kg (7230mg/kg)   Bitamin. Vol. 25, Pg. 297, 1962.
rabbit LDLo intravenous 2400mg/kg (2400mg/kg)   Archivum Immunologiae et Therapiae Experimentalis. Vol. 13, Pg. 70, 1965.
rat LD50 intraperitoneal 5400mg/kg (5400mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Archivum Immunologiae et Therapiae Experimentalis. Vol. 13, Pg. 70, 1965.
 
rat LD50 intravenous > 5gm/kg (5000mg/kg)   United States Patent Document. Vol. #3380887,
rat LDLo intracrebral 18mg/kg (18mg/kg)   Biochemical Pharmacology. Vol. 14, Pg. 1901, 1965.

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