112522-64-2 4-Acetylamino-N-(2'-aminophenyl)benzamide

Min.Order / FOB Price:Get Latest Price

1 Kilogram	FOB Price: USD 1000.0000

1 Kilogram

FOB Price: USD 1000.0000

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : L/C,T/T

Keywords

112522-64-2 4-Acetylamino-N-(2'-aminophenyl)benzamide C15H15N3O2

Quick Details

Appearance:white powder
Application:pharma
PackAge:as clients needs
ProductionCapacity:1|Metric Ton|Day
Storage:RT
Transportation:sea

Superiority:

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below:

1.Noble Metal Catalysts (Pt.Pd...)

2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...)

3.OLED intermediates (Fluorene,Carbazole,Boric acid...)

4.Customs Synthesis

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Details:

4-Acetylamino-N-(2'-aminophenyl)benzamide Chemical Properties

RTECS CU8702023

storage temp. Store at +4°C

solubility Soluble in DMSO

color off-white

Sensitive Air Sensitive

Safety Information

Hazard Codes Xi

Risk Statements 36

Safety Statements 26

MSDS Information

4-Acetylamino-N-(2'-aminophenyl)benzamide Usage And Synthesis

Uses Tacedinaline is a histone deacetylase (HDAC) inhibitor. Tacedinaline is an anti-cancer agent as HDAC inhibitors block angiogenesis, arrest cell growth, and lead to differentiation and apoptosis in tum or cells. Studies show Tacedinaline to be effective against acute myeloid leukemia in vitro and in vivo when used in combination with conventional anti-cancer agents.

Definition ChEBI: A benzamide obtained by formal condensation of the carboxy group of 4-acetamidobenzoic acid with one of the amino groups of 1,2-phenylenediamine. An oral cytostatic drug with impressive differential activity against leukemic cells and normal stem-cells. Al o used in combination therapy for selected tumors including non-smoll cell lung, pancreatic, breast, and colorectal cancers.

Biological Activity Orally active histone deacetylase (HDAC) inhibitor (K i values are 0.41, 0.75, >100 and >100 μ M for HDAC1, HDAC3, HDAC6 and HDAC8 respectively). Mediates G 1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo .

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