Acetylsalicylic acid 2-(acetyloxy)-benzoicaci 2-Acetyloxybenzoesαure
[pharmacological action] acetyl salicylic acid is one of the traditional antipyretic analgesics, as well as the role of platelet aggregation. Acetylsalicylic acid in the body has the characteristics of the antithrombotic, can reduce the surrounding the obstructive formation of blood clots in the arteries. The release of platelet inhibition reaction and endogenous release of ADP and 5 - HT. Therefore, the second phase inhibit platelet aggregation and not inhibit its first phase. The mechanism of action of acetyl salicylic acid is to make the platelet epoxy acetylation enzyme, thus inhibiting the formation of ring peroxide, TXA2 formation is also reduced. At the same time also can make the platelet membrane protein acetylation, and inhibit platelet membrane enzyme, which helps to inhibit platelet function. For ring oxidase is suppressed, therefore affect the vessel wall PGI2 synthesis; Also can make platelets TXA2 synthetic enzyme inhibition, such as large dose is TXA2 and PGI2 production are affected. Suitable for ischemic heart disease, coronary artery in operation (PTCA), coronary artery bypass surgery, can prevent transient ischemic stroke, myocardial infarction, reduce the incidence of arrhythmia.
The above information by Chemicalbook XiaoNan compiled (2015-09-17).
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