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68-41-7 D-Cycloserine Cas 68-41-7
Wuhan Fortuna Chemical Co.,Ltd is a professional integrative chemical enterprise with 18 years exporting experience,which is being engaged in Pharmaceutical and its intermediates, Food and Feed additives, Fine chemicals.
D-Cycloserine is a broad-spectrum antibiotic and NMDA receptor partial agonist with the following key aspects:
Structure: A cyclic derivative of the amino acid serine (C?H?N?O?), specifically the D-isomer (active form).
Antibiotic Action: Inhibits bacterial cell wall synthesis by blocking enzymes involved in peptidoglycan production (e.g., alanine racemase, D-alanine ligase).
Neurological Effect: Acts as a partial agonist at the glycine-binding site of NMDA receptors, modulating glutamate signaling to enhance synaptic plasticity and memory formation.
Tuberculosis: Second-line treatment for drug-resistant TB (adjunct to primary therapies).
Psychiatric Disorders: Investigated for augmenting exposure therapy in PTSD, phobias, and OCD by facilitating fear extinction.
Neurodegenerative Research: Studied in Alzheimer’s disease for cognitive enhancement.
Administration: Oral or intravenous.
Metabolism: Minimal hepatic processing; primarily excreted unchanged in urine.
CNS Effects: Dizziness, headache, seizures (rare).
Psychiatric: Anxiety, agitation (especially at high doses).
Contraindications: Avoid in epilepsy, severe renal impairment, or alcohol use (interaction risk).
Dose-Dependent Effects: Low doses enhance NMDA activity; high doses may block it.
Mixed Clinical Results: Efficacy varies in mental health trials, requiring precise timing with psychotherapy.
FDA-Approved: For TB and urinary tract infections (limited use due to resistance).
Off-Label: Experimental in psychiatry under strict protocols.
Summary: D-Cycloserine bridges microbiology and neuroscience, offering dual antibiotic and neuroplasticity-enhancing properties. While niche in clinical use, it remains a tool for studying memory and treating resistant infections.
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