CasNo.93479-97-1,Glimepiride,(93479-97-1) Suppliers

1 Kilogram	FOB Price: USD 581.3200

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : L/C,T/T

Keywords

AMARYL Glimepiride 93479-97-1

Quick Details

Appearance:white powder
Application:Glimepiride (original trade name Amaryl) is an orally available medium-to-long-acting sulfonylurea antidiabetic drug. It is sometimes classified as either the first third-generation sulfonylurea, or a
PackAge:10kg/drum
ProductionCapacity:500~1000 Kilogram/Month|Metric Ton|Day
Storage:Room temperature
Transportation:EMS、TNT、DHL、UPS、FEDEX、SF、Wuhan port Shanghai port Guangzhou port Tianjing port

Superiority:

1,we produce and sell good chemicals around the world.

2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%.

3,our staff consists of highly qualified individuals with bsc, msc and ph.d degrees in chemistry, as well as excellent carbohydrates,nucleosides, small molecules and rare chemicals.

4,imaginechem's chemists are skilled at performing complex, multi-step syntheses and solving difficult chemistry-related problems. because of our better, concentracted size and low overheads, we are able to offer prompt quotations, very competitive prices, high quality products and fast delivery.

5,all chemicals are typically >97% for building blocks, the structure and purity is confirmed by nmr and lc-ms. intermediates and final products are analyzed by gc, hplc, ir, nmr, ms, elemental analysis, atom-absorpting analysis and crystallographical methods.

6,Customers-oriented strategy, exclusive supply chain management, professional R&D team, experienced production workers, energetic sales team enable us to offer best service andgood-value products to all of our customers and gradually reach our final goals: becoming global leading supplier for portable products and solutions.

Details:

Glimepiride is the third generation sulfonylurea antidiabetic drug lasting effect, its fall blood sugar function is the main mechanism of the stimulus islet beta cells secrete insulin, some improve surrounding tissues to insulin sensitivity. This product with the speed of the insulin receptor and dissociation glyburide for fast, less cause heavier hypoglycemia. Its mechanism is through and sulfonyl urea receptors on the surface of the pancreatic beta cells (relative molecular mass of 6.5 x 104 protein), the receptor and ATP sensitive K + (KATP) channel phase coupling, pushing the KATP channel close, cause cell membrane depolarization, makes the open voltage dependent calcium channel, Ga2 + internal flow and lead to the release of insulin, and inhibit the synthesis of liver glucose. Recent research has shown that different sulfonyl urea coal medicine is different from the affinity of KATP. The following order: glibenclamide = Glenn beauty urea > tolbutamide > sulfonyl chloride propyl urea. In addition, Glenn beauty urea can increase by non-insulin-dependent heart glucose uptake, it could be a glucose transporter factor 1, 4 caused by two kinds of protein expression is increased. Due to Glenn beauty of urea to cardiovascular KATP channels in the weaker than Glenn wave urea, gliclazide pass column pyrazine. Cardiovascular adverse reaction is very few.