3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Min.Order / FOB Price:Get Latest Price

1 Gram	FOB Price:USD 480.0000 -500.0000

1 Gram

FOB Price:USD 480.0000 -500.0000

Min.Order :1 Gram
Purity: 99.0%
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline 641571-11-1

Quick Details

Appearance:White Powder
Application:intermediate for Erlotinib
PackAge:Bag/Drum
ProductionCapacity:1|Metric Ton|Day
Storage:In Cool Place
Transportation:Air/Sea

Superiority:

We specialized in APIS/ Intermediates and Focus on Technical more than 10 years.we have a perfect research and development technology and manufacturing. We have more advantages of technical and price.

Details:

Nilotinib (AMN107, trade name Tasigna), in the form of the hydrochloride monohydrate salt, is a tyrosine kinase inhibitor approved for the treatment of chronic myelogenous leukemia.

Nilotinib was approved as Tasigna in the USA and the EU for drug-resistant chronic myelogenous leukemia (CML). In June 2006, a Phase I clinical trial found nilotinib has a relatively favorable safety profile and shows activity in cases of CML resistant to treatment with imatinib (trade name:Gleevec [USA]/ Glivec [Europe/Australia/Latin America]), another tyrosine kinase inhibitor currently used as a first-line treatment. In that study 92% of patients (already resistant or unresponsive to imatinib) achieved a normal white blood cell counts after five months of treatment.The drug carries a black box warning for possible heart complications.The use of low doses of nilotinib is being investigated for use for Parkinson's and Alzheimer's disease, as well as for ALS, dementiaand Huntington's disease.