Sofosbuvir 1190307-88-0 Best price Sofosbuvir
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Sofosbuvir Preparation Products And Raw materials |
Sofosbuvir Basic information |
Product Name: | Sofosbuvir |
Synonyms: | Sofosbuvir (PSI-7977, GS-7977);Sofosbuvir N-[[P(S),2'R]-2'-Deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-methylethyl ester;propan-2-yl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate;Suofeibuwei;Sofosbuvir, >=98%;Sofosbubir;Sofosbuvir,GS-7977;(S)-Isopropyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-h |
CAS: | 1190307-88-0 |
MF: | C22H29FN3O9P |
MW: | 529.4525242 |
EINECS: | 11-000-0 |
Product Categories: | API;Inhibitors;Liver Disease Series;PSI7977;Pharmaceutical intermediate |
Mol File: | 1190307-88-0.mol |
Sofosbuvir Chemical Properties |
density | 1.41 |
CAS DataBase Reference | 1190307-88-0 |
Safety Information |
HS Code | 29339900 |
Description | Sofosbuvir is a drug used for the treatment of hepatitis C. It is recommended to be used in combination with other drugs (such as velpatasvir) for the first-line treatment for HCV genotypes 1, 2, 3, 4, 5, and 6. It takes effect through acting as a nucleotide analog inhibitor, being capable of specially inhibiting the HCV NS5B (non-structural protein 5B) RNA-dependent RNA polymerase. |
Uses | PSI-7977 is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the t reatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase. |
Definition | ChEBI: A nucleotide conjugate that is used in combination with ledipasvir (under the trade name Harvoni) for the treatment of chronic hepatitis C genotype 1 infection. |
Uses | PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM). PSI-7977 is effective in vitro and in vivo.[Cayman Chemical] |
Sofosbuvir Preparation Products And Raw materials |
Advantages:
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