Factory Supply Diltiazem HCl CAS 33286-22-5 Diltiazem Hydrochloride Powder
Introduction
CAS RN.: 33286-22-5
EINECS: 251-443-3
Molecular Weight: 450.9788
Molecular Formula: C22H27ClN2O4S
Melting Point(℃): 210-215℃
Boiling Point(℃): 594.4°C at 760 mmHg
Flash Point(℃): 313.3°C
Water Solubility: soluble
Function
Diltiazem is a nondihydropyridines (non-DHP) calcium channel blocker used in the treatment of hypertension, angina pectoris, and some types of arrhythmia. It relaxes the smooth muscles in the walls of arteries, which opens (dilates) the arteries, allows blood to flow more easily, and lowers blood pressure. Additionally, it lowers blood pressure by acting on the heart itself to reduce the rate, strength, and conduction speed of each beat.
Application
Diltiazem hydrochloride is an antihypertensive and cardioprotective agent as well as a calcium channel protein inhibitor. It inhibits L-type Ca2+ channels and regulates Ca2+ release from intracellular stores in neutrophils.
Specification
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Items |
Standard |
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Character |
White or almost white crystalline powder |
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Identification |
Positive |
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Residue on ignition |
≤0.5% |
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Heavy metals |
NMT 20ppm |
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Arsenic |
NMT 5ppm |
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Sulphated ash |
NMT 0.1% |
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Loss on drying |
NMT 0.5% |
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Total impurities |
NMT 1.5% |