High Purity Ornidazole CAS:16773-42-5

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10 Gram	Negotiable

10 Gram

Negotiable

Min.Order :10 Gram
Purity: 99%
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Ornidazole CAS:16773-42-5 High Purity Ornidazole

Quick Details

Appearance:White Crystalline Powder
Application:It Can Be Used As Pharmaceutical Intermediates Etc.
PackAge:100g/ bag, 2 kg/ bag, 25kg/ carton or as required
ProductionCapacity:1000|Metric Ton|Month
Storage:Store in sealed containers at cool & dry place. Protect from light, moisture and pest infestation.
Transportation:By DHL, TNT, FedEx, HKEMS, UPS, Etc

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High Purity Ornidazole CAS:16773-42-5

Ornidazole Basic information

Description Indications Contraindications Dosage Information Mechanism of Action Drug Interactions Warnings Pharmacokinetics Side Effects Side Effects Side Effects Side Effects Side Effects Side Effects

Product Name:	Ornidazole
Synonyms:	alpha-(chlormethyl)-2-methyl-5-nitro-imidazol-1-aethanol;alpha-(chloromethyl)-2-methyl-5-nitro-1h-imidazole-1-ethano;alpha-(chloromethyl)-2-methyl-5-nitro-imidazole-1-ethano;ro7-0207;tiberal;ORNIDAZOLE;TIMTEC-BB SBB006918;LABOTEST-BB LT00772185
CAS:	16773-42-5
MF:	C7H10ClN3O3
MW:	219.63
EINECS:	240-826-0
Product Categories:	Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Intermediates & Fine ChemicalsHeterocycles;API;alcohol\| alkyl chloride\| nitro-compound;OGEN;disinfectant
Mol File:	16773-42-5.mol

Ornidazole Chemical Properties

Melting point	85-90°C
density	1.6545 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	-20°C Freezer
solubility	Soluble in ethanol at 50mg/ml
pka	2.4 ± 0.1(at 25℃)
λmax	276nm(H2SO4 aq.)(lit.)
Merck	14,6872
CAS DataBase Reference	16773-42-5(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn
Risk Statements	22
Safety Statements	36
WGK Germany	3
RTECS	NI5460000
HazardClass	IRRITANT
Toxicity	LD50 in rats, mice (mg/kg): 1780, 1420 orally (Grunberg); LD50 in mice (mg/kg): >2000 orally, >2000 i.p. (Hoffer, Grunberg)

MSDS Information

Provider	Language
1(3-chloro-2-hydroxypropyl)-2-methyl-5-nitro imidazole	English
SigmaAldrich	English

Ornidazole Usage And Synthesis

Description	Ornidazole is prescribed for the treatment of certain protozoan infections, post-surgery infections and bacterial infections. The action of this drug is based on its potential to inhibit the development of microorganisms. Ornidazole is available as an oral tablet that should be taken based on a pharmacist/doctor’s instructions. Prescriptions that include this drug should also take into consideration some of the patient’s specifications such as hypersensitivity and potential drug interactions.
Indications	Ornidazole is given to patients who have vaginal infections such as bacterial vaginitis, post-surgical infections, anaerobic bacterial infections, skin infections, trichomonas vaginitis, intestinal infections, stomach infections, parasitic infections and bacterial infections. It is highly recommended that this drug is taken under appropriate diagnosis and medical indication.
Contraindications	It is not recommended to take this medicine if one is hypersensitive to similar antibiotics, or if one has a history of hypersensitivity. Other than hypersensitivity, this drug is contraindicated in lactating/pregnant women, and in patients with epilepsy, myasthenia gravis and multiple sclerosis.
Dosage Information	For the treatment of amoebiasis, adult patients should take 1g daily in 2 doses for 7-10 days whereas children should be given 10-25mg/kg once a day for 3 days. For treatment of amoebic dysentery, adults should take 1.5mg once a day for 3 days whereas children should be given 40mg/kg once per day for 3 days. The typical Ornidazole dosage for treatment of trichomoniasis in adults is 0.5gm once every 12 hours/1.5gm as a single dose for 5 days. In children, 25mg/kg can be taken as a single dose. For treatment of Giardiasis in adults, 1-1.5gm should be taken once per day for 2 days and in children, 40mg/kg should be taken for two days. The dosage requirements for the treatment of bacterial vaginitis is 1.5gm, which is taken once every day or 500mg taken as a daily single dose for 5-7 days. In the event of a missed dose, supportive and symptomatic treatment should be commenced where the Ornidazole is removed through gastric lavage, induced emesis, application of a carthartic or administration of activated charcoal.
Mechanism of Action	The drug is a nitroimidazole with broad spectrum cidal action against specific types of anaerobic bacteria and protozoa. Ornidazole’s selective toxicity in response to anaerobic microbes entails entry of the drug into the cell through diffusion and reduction of the drug’s nitro group into reactive nitro by redox proteins in anaerobic organisms. This activity influences cytotoxic action by destroying DNA and other fundamental molecules. The final step entails destabilization of the DNA helix and the breakage of certain strands.
Drug Interactions	Some medications have a higher probability of interacting with other prescription drugs hence the doctor should approve any medication adjustments. It is essential for a patient to notify their doctor of any medication, herbal treatments and vitamin supplements that they may be taking before the administration of Ornidazole. A prompt notification may minimize the probability of occurrence of specific side effects. Ornidazole may interact with warfarin and vecuronium.
Warnings	It is recommended that a patient abstains from alcohol intake for at least 3 days after initiation of therapy with this drug. Alcohol use or associated products may influence disulfiram-like responses in some people. Ornidazole use in pregnant/breastfeeding women is not recommended as the potential risks may outweigh the benefits in some cases. However, a patient should always consult their healthcare practitioner before taking this medication. The use of Ornidazole may result in drowsiness hence a patient should avoid activities such as the operation of heavy machinery and driving during the first stages of treatment with this drug. Caution should be taken amongst patients with multiple sclerosis as it is a neurodegenerative disorder associated with the brain. Ornidazole should not be prescribed for patients with convulsion disorders such as epilepsy. For patients with hepatic/renal impairment, the drug should be used cautiously as it may intensify the severity of the pre-existing condition. In this case, it is recommended that the patient is monitored frequently by their doctor for mild to moderate impairment and the respective dose modifications.
Pharmacokinetics	Ornidazole is absorbed well orally, and it is widely distributed through the body. The drug undergoes metabolism in the liver and part of the drug is excreted in bile whereas the rest is eliminated in urine. The duration of action of the drug is 14 hours.
Side Effects	In the administration of medications to treat specific medical conditions, there is a high probability that unintended side effects will develop. Patients on Ornidazole treatment may experience some of the associated side effects in varying intensities. However, if the symptoms persist for an extended period, the patient should contact their doctor. Potential side effects may include hormonal imbalances in the thyroid gland, skin rash, urticaria, abdominal distress, vertigo metallic taste, dry mouth, upset stomach, drowsiness, headache and nausea.
Side Effects	In the administration of medications to treat specific medical conditions, there is a high probability that unintended side effects will develop. Patients on Ornidazole treatment may experience some of the associated side effects in varying intensities. However, if the symptoms persist for an extended period, the patient should contact their doctor. Potential side effects may include hormonal imbalances in the thyroid gland, skin rash, urticaria, abdominal distress, vertigo metallic taste, dry mouth, upset stomach, drowsiness, headache and nausea.
Side Effects	In the administration of medications to treat specific medical conditions, there is a high probability that unintended side effects will develop. Patients on Ornidazole treatment may experience some of the associated side effects in varying intensities. However, if the symptoms persist for an extended period, the patient should contact their doctor. Potential side effects may include hormonal imbalances in the thyroid gland, skin rash, urticaria, abdominal distress, vertigo metallic taste, dry mouth, upset stomach, drowsiness, headache and nausea.
Side Effects	In the administration of medications to treat specific medical conditions, there is a high probability that unintended side effects will develop. Patients on Ornidazole treatment may experience some of the associated side effects in varying intensities. However, if the symptoms persist for an extended period, the patient should contact their doctor. Potential side effects may include hormonal imbalances in the thyroid gland, skin rash, urticaria, abdominal distress, vertigo metallic taste, dry mouth, upset stomach, drowsiness, headache and nausea.
Side Effects	In the administration of medications to treat specific medical conditions, there is a high probability that unintended side effects will develop. Patients on Ornidazole treatment may experience some of the associated side effects in varying intensities. However, if the symptoms persist for an extended period, the patient should contact their doctor. Potential side effects may include hormonal imbalances in the thyroid gland, skin rash, urticaria, abdominal distress, vertigo metallic taste, dry mouth, upset stomach, drowsiness, headache and nausea.
Side Effects	In the administration of medications to treat specific medical conditions, there is a high probability that unintended side effects will develop. Patients on Ornidazole treatment may experience some of the associated side effects in varying intensities. However, if the symptoms persist for an extended period, the patient should contact their doctor. Potential side effects may include hormonal imbalances in the thyroid gland, skin rash, urticaria, abdominal distress, vertigo metallic taste, dry mouth, upset stomach, drowsiness, headache and nausea.
Chemical Properties	Crystalline Solid
Uses	Anti-infective
Uses	estrogen
Definition	ChEBI: A C-nitro compound that is 5-nitroimidazole in which the hydrogens at positions 1 and 2 are replaced by 3-chloro-2-hydroxypropyl and methyl groups, respectively. It is used in the treatment of susceptible protozoal infections and for the treatment of anaerobic bacterial infections.

Ornidazole Preparation Products And Raw materials

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High Purity Ornidazole CAS:16773-42-5

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