Fingolimod hydrochl...

Fingolimod hydrochloride(4-fingolimod intermediate),CAS 162359-56-0 ,pharmaceutical

Fingolimod hydrochloride(4-fingolimod intermediate),CAS 162359-56-0 ,pharmaceutical

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162359-56-0 Fingolimod hydrochloride C19H34ClNO2

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Fingolimod hydrochloride(4-fingolimod intermediate),CAS 162359-56-0 ,pharmaceutical

Fingolimod hydrochloride Basic information
Oral drug for the treatment of multiple sclerosis
Product Name: Fingolimod hydrochloride
Synonyms: Fingolimod (FTY720) hydrochloride;Fin;limod hydrochloride;fingolimod hydrochloride;FTY720;2-AMINO-2-[2-(4-OCTYLPHENYL)ETHYL]-1,3-PROPANEDIOL, HYDROCHLORIDE;2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride;Fingolimod HCl
CAS: 162359-56-0
MF: C19H34ClNO2
MW: 343.93
EINECS: 1308068-626-2
Product Categories: All Inhibitors;Inhibitors;Metabolites;Pharmaceutical intermediate;Pharmaceuticals;Aromatics;Intermediates & Fine Chemicals;Metabolites & Impurities;API;Other APIs
Mol File: 162359-56-0.mol
Fingolimod hydrochloride Structure
 
Fingolimod hydrochloride Chemical Properties
Melting point  102-107°C
storage temp.  -20°C Freezer
solubility  water: soluble10mg/mL, clear
color  white to beige
Merck  14,4083
CAS DataBase Reference 162359-56-0(CAS DataBase Reference)
 
Safety Information
Hazard Codes  Xi
Risk Statements  36/37/38-52/53
Safety Statements  26-61
RTECS  TY3130000
HS Code  29221990
Toxicity LD50 orally in rats: 300-600 mg/kg (Troncoso)
 
Chemical Properties White Solid
Uses A derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibitin
Uses A derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. t is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. Reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
Uses Oral medicine for the treatment of multiple sclerosis
Uses FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. FTY720 is a novel immune modulator that prolong s allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 us reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
Uses A cell-permeable aminopropanediol immunosuppressive agent that displays lymphocyte sequestration properties.

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Fingolimod hydrochloride(4-fingolimod intermediate),CAS 162359-56-0 ,pharmaceutical

 

 

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