Introduction:
Mucuna pruriens extract L-dopa that is made and used as part of the normal biology of humans, some animals and plants. Some animals and humans make it via biosynthesis from the amino acid L-tyrosine. L-dopa is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline) collectively known as catecholamines. Furthermore, L-dopa itself mediates neurotrophic factor release by the brain and CNS.
L-DOPA has a counterpart with opposite chirality, D-DOPA. As is true for many molecules, the human body produces only one of these isomers (the L-DOPA form). The enantiomeric purity of L-DOPA may be analyzed by determination of the optical rotation or by chiral thin-layer chromatography (TLC).
Function:
Levodopa has significant effects in improving myotonia and bradykinesia. Continuous medication is also effective in treating tremors, salivation, postural instability and dysphagia.
1. Main indication: Parkinson's disease (essential paralysis of paralysis)
Post-encephalitis or symptomatic Parkinson's syndrome (non-invasive paralysis syndrome) after cerebral arteriosclerosis and central nervous system carbon monoxide and manganese poisoning. L-dopa can reduce the symptoms of paralysis, improve muscle tone, and make normal body movement more normal. The effect is better for patients with mild to moderate disease, and worse for patients with severe or elderly disease.
2. Hepatic encephalopathy
L-dopa can allow the patient to wake up and improve symptoms. Hepatic encephalopathy may be related to the central transmitter dopamine abnormalities, and after taking, can improve the central function and work. It has also been suggested that levodopa can increase the tolerance of the brain to ammonia, but it does not improve liver damage and liver function.
3. Neuralgia
Early use can relieve neuralgia.
4. Hyperprolactinemia
L-dopa can inhibit the hypothalamus thyrotropin releasing hormone and stimulate the secretion of prolactin, thus reducing the secretion of prolactin. It is used to treat hyperprolactinemia and has a certain effect on the treatment of the disease.
5. Alopecia
The mechanism of L-dopa may be to increase the concentration of blood catecholamines in the tissues and promote hair growth.
6. Promote growth and development in children
L-dopa can accelerate the growth and development of pediatric bones by promoting the secretion of growth hormone. Treatment of children with hypopituitarism.
Specification: