High quality Saxagliptin(361442-04-8)

Introduction:

Saxagliptin is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs.This compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.

Pharmacodynamics:

Post-administration of saxagliptin, GLP-1 and GIP levels rise up to 2- to 3- fold. Because it is very selective of DPP-4 inhibition, there are fewer systemic side effects. Saxagliptin inhibits DPP-4 enzyme activity for a 24-hour period. It also decreased glucagon concentrations and increased glucose-dependent insulin secretion from pancreatic beta cells. The half maximal inhibitory concentration (IC50) is 0.5 nmol/L. Saxagliptin did not prolong the QTc interval to a clinically significant degree.

Mechanism of Action:

Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor antidiabetic for the treatment of type 2 diabetes. DPP-4 inhibitors are a class of compounds that work by affecting the action of natural hormones in the body called incretins. Incretins decrease blood sugar by increasing consumption of sugar by the body, mainly through increasing insulin production in the pancreas, and by reducing production of sugar by the liver. [Bristol-Myers Squibb Press Release] DPP-4 is a membrane associated peptidase which is found in many tissues, lymphocytes and plasma. DPP-4 has two main mechanisms of action, an enzymatic function and another mechanism where DPP-4 binds adenosine deaminase, which conveys intracellular signals via dimerization when activated. Saxagliptin forms a reversible, histidine-assisted covalent bond between its nitrile group and the S630 hydroxyl oxygen on DPP-4. The inhibition of DPP-4 increases levels active of glucagon like peptide 1 (GLP-1), which inhibits glucagon production from pancreatic alpha cells and increases production of insulin from pancreatic beta cells.

Specification

 25kg carton drum (32cm*58cm)or 1kg foil bag (10cm*15cm) or by request of clients

Transit could be DHL,UPS,TNT,EMS,Fedex,and so on.

For mass orders, it will be delivered by air or sea.

 1. Your inquiry related to our products or prices will be replied in 12hours.

2. Well-trained and experienced staffs to answer your enquires in fluent English.

3. All our products have high quality warranties.

4. Sample order can be delivered within 3 working days, small order 3-5working days, mass order 7-10working days.

5. Samples can be offered by free,customers just need to pay the freight.But the freight can be returned to our customer after he/she places formal order with us. 

QDOCEAN Import And Export Co., Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.

The aim of QDOCEAN is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.

QDOCEAN has become the "Top 500 Chinese manufacturing companies","Top 20 of global agrochemical sales".QDOCEAN has 21 subsidiaries and holding companies.

Q1: Are you a manufacturer
Answer: Yes, we are factory founded on 2002.

Q2: How to contact with us
Click the Alibaba "Contact Supplier" And then send us message the product you interest in, you will get reply within 24 hours.

Q3:Which kind of payment terms do you accept
For small order,you can pay by T/T, or Paypal,nomal order by T/T to our company account

Q4:Can you give me a discount price
Surely,It depend on your qty

Q5:How can i get a sample
free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future.

Q6: How to confirm the Product Quality before placing orders
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q7:How do you treat quality complaint
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.