High quality AICAR with best price 2627-69-2

Name: Aicar

CAS No: 2627-69-2

Molecular Formular: C9H14N4O5

Molecular Weight: 258.2 

Appearance: Off-white powder

Chemical name: 5-Aminoimidazole-4-carboxamide ribonucleotide

Package size: 1g/5g/10g/100g or as per customers' requirement

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Name: Aicar

CAS No: 2627-69-2

Molecular Formular: C9H14N4O5

Molecular Weight: 258.2 

Appearance: Off-white powder

Chemical name: 5-Aminoimidazole-4-carboxamide ribonucleotide

Package size: 1g/5g/10g/100g or as per customers' requirements

Uses

AICAR (AICA-Riboside) strongly inhibits the transcription of PPARα and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC).

Application

(1) Applied in phamaceutical field, it is used as phamaceutical raw material to treat injuries from fall, infectious hepatitis and epidemic cerebrospinal meningitis. 
(2) Applied in healthcare field, it is used in the health products to nourish brain, protect liver and improve sleep quality.
(3) Applied in comestics, it is used to promote skin metabolism and make skin more tender and firm.