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ciclopirox olamine 41621-49-2 ciclopirox olamine Price
1) Product Name: Ciclopirox ethanolamine
2) CAS NO: 41621-49-2
3) Specification: 99%
4) Testing Method:HPLC
5) Appearance: White powder
6) Introduction:Ciclopirox olamine is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. It is most useful against Tinea versicolor.
Certification of Analysis
Item |
Specifications |
Results |
Discriminate |
IR absorption Conforms to standard |
Conforms |
Description |
White crystalline powder |
Conforms |
Ciclopirox Olamine content |
97.5%~101.5% |
99.55% |
Ethanolamine content |
223~230mg/g |
225mg/g |
Residue on ignition |
≤0.1% |
0.05% |
Loss drying |
≤1.5% |
0.55% |
PH value |
8.0-9.0 |
8.4 |
Heavy metals content |
≤10ppm |
Conforms |
Related substance |
impurityA<0.5% impurities<0.5% any impurities<0.1% |
Conforms |
Solubility |
Soluble in alcohol and organic solvents such as dichloromethane and slightly in water |
Conforms |
Residual solvents |
dichloromethane<600ppm toluene<890ppm erthyl<5000ppm |
dichloromethane<250ppm toluene<280ppm erthyl<1200ppm |
Conclusion |
The results conforms with USP32 standards. |
Function&Application
Ring pyrazole amine is a kind of anti-infection drugs, pharmaceutical factory successfully developed by the federal Germany, mechanism of action is by changing the fungal cell membrane integrity, cause the outflow in the cell, and blocking the protein precursor uptake, led to the deaths of fungal cells, the skin tinea bacteria, yeast and mold have stronger bacteriostasis and sterilization effect, permeability is strong.High concentration can also be a variety of actinomycetes, gram-positive and gram-negative bacteria and mycoplasma, chlamydia, trichomonas, vaginal trichomoniasis and pseudomonas aeruginosa also have a certain inhibition.
Compared with imidazole anti-infective agents, cyclopyrmidine has a strong permeation to the cuticle on which the skin fungi live. Therefore, it has a significant antibacterial effect on the deeper fungi of the cuticle, such as tinea.
Clinically, it is mainly used for the treatment of superficial fungal infections of skin, such as body ringworm, athlete's foot, tinea manus, tinea manus (especially hyperkeratosis), tinea tinea, candidiasis of skin, candida albicans and tinea.
Real Photo
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