Astragaloside

Natural Astragalus Root Extract /Polysaccharides:30%-95% Astragaloside:5%-20%

Latin Name:  Astragalus membranaceus(Fisch.)Bge.
Active Ingredients: Polysaccharides 10%-70%, Astragalosides 0.1%-98%
Part Used: Root
Variety: Astragalus root extract
Appearance: Brown-yellow fine powder
Extraction Type: Solvent extraction
Test Method: UV&HPLC
Sieve analysis: 100% pass 80 mesh
 

Composition
Astragalus root has polysaccharides that have a role in influencing the immune system. Astragalus root also contains saponins called astragalosides and astramembranosides, along with flavonoids and triterpenes. Three major flavonoids are ononin, along with formononetin, and demethylhomopterocarpin.
 

Benefits of Astragalus extract

Aplastic anemia
Sixty patients with aplastic anemia were randomly assigned to two groups equally, both were treated with Stanozolol three times a day, 2 mg each time through oral intake, but astagalus was given additionally to the patients in the treated group once a day via intravenous dripping. All were treated for 15 days as one therapeutic course and the whole medication lasted for more than 4 months totally, with follow-up adopted. 

Anti-inflammatory action
Int J Mol Med. 2013. Astragalus polysaccharide induces anti-inflammatory effects dependent on AMPK activity in palmitate-treated RAW264.7 cells. School of Basic Medical Sciences, Wuhan University, Wuhan, P.R. China.

Blood sugar
Astragalus polysaccharide exerts insulin-sensitizing and hypoglycemic activities in type 2 diabetic rats. The present study was designed to confirm the hypoglycemic effect of Astragalus polysaccharide and to investigate its possible mechanism underlying the improvement of insulin resistance in vivo and in vitro. We found Astragalus polysaccharide could alleviate insulin resistance induced by high glucose. The hyperglycemia, hypolipemia, and hyperinsulinemia status were controlled with Astragalus polysaccharide therapy. Insulin action in the liver of insulin resistant mice was restored significantly with Astragalus polysaccharide administration. The anti-obesity effect and hypolipidemia effects of Astragalus polysaccharide were probably due partly to decreasing the leptin resistance of mice, which would positively couple with the normalization of plasma insulin levels.

Brain cells
Chin Med J. Protective effects of astragalus extract against intermittent hypoxia-induced hippocampal neurons impairment in rats. School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China; Tianjin Institute of Geriatrics, Tianjin Medical University General Hospital, Tianjin, China.

Cancer and use with chemotherapy medicine

Anthracyclines are antitumor antibiotics with significant activity against solid and hematologic malignancies. One problem preventing more widespread use has been the development of cardiotoxicity. To determine whether antioxidant agents can reduce the cardiotoxicity of anthracyclines, Astragalus membranaceus was introduced. Pre-treatment with Astragalus membranaceus significantly attenuated the daunorubicin-induced increases of reactive oxygen species, apoptosis and the secretions of LDH in cultured neonatal cardiomyocytes. 

Fatigue
Alteration of immune function may be associated with chronic fatigue syndrome (CFS) and this study reveals the immunoregulatory effect of Astragalus membranaceus flavonoids. Rats were induced by food intake restriction plus forced swimming for 6 weeks. An atrophied spleen associated with a significantly decreased spleen/body weight ratio and a reduced spleen cells proliferation was found in these rats when compared with home cage controls. Astragalus membranaceus flavonoids given orally at 20, 50 and 100mg/kg body weight once a day consecutively for 6 weeks recovered the reduced cell proliferation. A switch to Th1-dominated immune regulation was observed in these rats as the cultured splenocytes produced more interleukin-2 (IL-2) but less IL-4 when compared with controls. Supplementation with Astragalus membranaceus flavonoids counteracted the aberrant cytokine production and rats receiving Astragalus membranaceus flavonoids exhibited higher endurance capacity to swim when compared with those without the herb. 

Heart failure

To observe the clinical efficacy and side-effects of Astragalus Injection in treating congestive heart failure (CHF). Eighty-three CHF patients with heart function of II-IV grade assessed by New York Heart Association classification were randomly divided into 2 groups. The 42 patients in the treated group were treated with astragalus 40 ml (equivalent to 80 g crude drug) by adding in 5% glucose solution 500 ml for intravenous dripping, once a day and the 41 patients in the control group were treated by nitrolingual injection. The therapeutic course in both groups was 2 weeks and the patients were followed-up for 1- 6 months. The clinical heart function improvement rate and the total effective rate in the astragalus treated group after 1 month treatment were 26% and 78%, and after 6 months were 34% and 81% respectively, which were superior to those in the control group significantly. 

Immune system
Astragalus improves certain parts of the immune system, and may have some anti-HIV activity. It's not clear whether astragalus would have anti-HIV activity when ingested as a supplement.

Certification Of Analysis

Packing:

1.Packing: By 25kgs/drum, inner by double plastic bag.

2. Storage: Stored in a cool & dry well-closed container, keep away from moisture and strong light/heat.

3. Shelf life: Two years under well storage situation.